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dc.contributor.authorKhan, Farhat
dc.contributor.authorRadovanovic, Aleksandar
dc.contributor.authorGojobori, Takashi
dc.contributor.authorKaur, Mandeep
dc.date.accessioned2021-06-07T12:18:47Z
dc.date.available2021-06-07T12:18:47Z
dc.date.issued2021-04-30
dc.date.submitted2020-12-28
dc.identifier.citationKhan, F., Radovanovic, A., Gojobori, T., & Kaur, M. (2021). IBDDB: a manually curated and text-mining-enhanced database of genes involved in inflammatory bowel disease. Database, 2021. doi:10.1093/database/baab022
dc.identifier.issn1758-0463
dc.identifier.doi10.1093/database/baab022
dc.identifier.urihttp://hdl.handle.net/10754/669439
dc.description.abstractTo date, research on inflammatory bowel disease (IBD, encompassing Crohn's disease and ulcerative colitis), a chronic complex disorder, has generated a large amount of data scattered across published literature (1 06 333) listed in PubMed on 14 October 2020, and no dedicated database currently exists that catalogues information on genes associated with IBD. We aimed to manually curate 289 genes that are experimentally validated to be linked with IBD and its known phenotypes. Furthermore, we have developed an integrated platform providing information about different aspects of these genes by incorporating several resources and an extensive text-mined knowledgebase. The curated IBD database (IBDDB) allows the selective display of collated 34 subject-specific concepts (listed as columns) exportable through a user-friendly IBDDB portal. The information embedded in concepts was acquired via text-mining of PubMed (manually cleaned and curated), accompanied by data-mining from varied resources. The user can also explore different biomedical entities and their co-occurrence with other entities (about one million) from 11 curated dictionaries in the indexed PubMed records. This functionality permits the user to generate and cross-examine a new hypothesis that is otherwise not easy to comprehend by just reading the published abstracts and papers. Users can download required information using various file formats and can display information in the form of networks. To our knowledge, no curated database of IBD-related genes is available so far. IBDDB is free for academic users and can be accessed at https://www.cbrc.kaust.edu.sa/ibd/.
dc.description.sponsorshipThis work was supported by funding from the King Abdullah University of Science and Technology (KAUST), Saudi Arabia [award number FCC/1/1976-20-01].
dc.publisherOxford University Press (OUP)
dc.relation.urlhttps://academic.oup.com/database/article/doi/10.1093/database/baab022/6260885
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleIBDDB: a manually curated and text-mining-enhanced database of genes involved in inflammatory bowel disease
dc.typeArticle
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.identifier.journalDatabase : the journal of biological databases and curation
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionSchool of Molecular and Cell Biology, University of the Witwatersrand, Private Bag 3, Johannesburg, South Africa
dc.identifier.volume2021
kaust.personRadovanovic, Aleksandar
kaust.personGojobori, Takashi
kaust.grant.numberFCC/1/1976-20-01
dc.date.accepted2021-04-17
dc.identifier.eid2-s2.0-85105221371
refterms.dateFOA2021-06-07T12:19:45Z


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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited
Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited