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dc.contributor.authorCongiu, Terenzio
dc.contributor.authorAlghrably, Mawadda N.
dc.contributor.authorEmwas, Abdul-Hamid M.
dc.contributor.authorJaremko, Lukasz
dc.contributor.authorLachowicz, Joanna Izabela
dc.contributor.authorPiludu, Marco
dc.contributor.authorPiras, Monica
dc.contributor.authorFaa, Gavino
dc.contributor.authorPichiri, Giuseppina
dc.contributor.authorJaremko, Mariusz
dc.contributor.authorConi, Pierpaolo
dc.date.accessioned2021-06-06T05:43:27Z
dc.date.available2021-06-06T05:43:27Z
dc.date.issued2021-06-03
dc.date.submitted2021-04-30
dc.identifier.citationCongiu, T., Alghrably, M. N., Emwas, A.-H., Jaremko, L., Lachowicz, J. I., Piludu, M., … Coni, P. (2021). Undercover Toxic Ménage à Trois of Amylin, Copper (II) and Metformin in Human Embryonic Kidney Cells. Pharmaceutics, 13(6), 830. doi:10.3390/pharmaceutics13060830
dc.identifier.issn1999-4923
dc.identifier.doi10.3390/pharmaceutics13060830
dc.identifier.urihttp://hdl.handle.net/10754/669367
dc.description.abstractIn recent decades, type 2 diabetes complications have been correlated with amylin aggregation, copper homeostasis and metformin side effects. However, each factor was analyzed separately, and only in some rare cases copper/amylin or copper/metformin complexes were considered. We demonstrate for the first time that binary metformin/amylin and tertiary copper (II)/amylin/metformin complexes of high cellular toxicity are formed and lead to the formation of aggregated multi-level lamellar structures on the cell membrane. Considering the increased concentration of amylin, copper (II) and metformin in kidneys of T2DM patients, our findings on the toxicity of amylin and its adducts may be correlated with diabetic nephropathy development.
dc.description.sponsorshipThis research was partially funded by FIR 2020 and from Regione Autonoma della Sardegna (grant RASSR79857).
dc.publisherMDPI AG
dc.relation.urlhttps://www.mdpi.com/1999-4923/13/6/830
dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleUndercover Toxic Ménage à Trois of Amylin, Copper (II) and Metformin in Human Embryonic Kidney Cells
dc.typeArticle
dc.contributor.departmentDivision of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.
dc.contributor.departmentNMR
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.identifier.journalPharmaceutics
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionDepartment of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, Italy.
dc.contributor.institutionDepartment of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Italy.
dc.contributor.institutionConsorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase (CSGI), via della Lastruccia 3, 50019 Sesto Fiorentino, Italy.
dc.identifier.volume13
dc.identifier.issue6
dc.identifier.pages830
kaust.personAlghrably, Mawadda N.
kaust.personEmwas, Abdul-Hamid M.
kaust.personJaremko, Lukasz
kaust.personJaremko, Mariusz
dc.date.accepted2021-05-28
refterms.dateFOA2021-06-06T05:45:18Z


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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
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