Undercover Toxic Ménage à Trois of Amylin, Copper (II) and Metformin in Human Embryonic Kidney Cells
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ArticleAuthors
Congiu, TerenzioAlghrably, Mawadda N.
Emwas, Abdul-Hamid M.

Jaremko, Lukasz

Lachowicz, Joanna Izabela

Piludu, Marco
Piras, Monica
Faa, Gavino
Pichiri, Giuseppina
Jaremko, Mariusz

Coni, Pierpaolo
KAUST Department
Biological and Environmental Science and Engineering (BESE) DivisionBioscience Program
NMR
Date
2021-06-03Submitted Date
2021-04-30Permanent link to this record
http://hdl.handle.net/10754/669367
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In recent decades, type 2 diabetes complications have been correlated with amylin aggregation, copper homeostasis and metformin side effects. However, each factor was analyzed separately, and only in some rare cases copper/amylin or copper/metformin complexes were considered. We demonstrate for the first time that binary metformin/amylin and tertiary copper (II)/amylin/metformin complexes of high cellular toxicity are formed and lead to the formation of aggregated multi-level lamellar structures on the cell membrane. Considering the increased concentration of amylin, copper (II) and metformin in kidneys of T2DM patients, our findings on the toxicity of amylin and its adducts may be correlated with diabetic nephropathy development.Citation
Congiu, T., Alghrably, M. N., Emwas, A.-H., Jaremko, L., Lachowicz, J. I., Piludu, M., … Coni, P. (2021). Undercover Toxic Ménage à Trois of Amylin, Copper (II) and Metformin in Human Embryonic Kidney Cells. Pharmaceutics, 13(6), 830. doi:10.3390/pharmaceutics13060830Sponsors
This research was partially funded by FIR 2020 and from Regione Autonoma della Sardegna (grant RASSR79857).Publisher
MDPI AGJournal
PharmaceuticsAdditional Links
https://www.mdpi.com/1999-4923/13/6/830ae974a485f413a2113503eed53cd6c53
10.3390/pharmaceutics13060830
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