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dc.contributor.authorSteverlynck, Joost Andre
dc.contributor.authorSitdikov, Ruzal
dc.contributor.authorRueping, Magnus
dc.date.accessioned2021-06-03T07:14:49Z
dc.date.available2021-06-03T07:14:49Z
dc.date.issued2021-07-07
dc.date.submitted2021-04-01
dc.identifier.citationSteverlynck, J., Sitdikov, R., & Rueping, M. (2021). The Deuterated “Magic Methyl“ Group - A Guide for Site-selective Trideuteromethyl Incorporation and Labeling using CD3-reagents. Chemistry – A European Journal. doi:10.1002/chem.202101179
dc.identifier.issn0947-6539
dc.identifier.issn1521-3765
dc.identifier.doi10.1002/chem.202101179
dc.identifier.doi10.1002/chem.202184661
dc.identifier.urihttp://hdl.handle.net/10754/669361
dc.description.abstractIn the field of medicinal chemistry the precise installation of a trideuteromethyl group is gaining ever-increasing attention. Site-selective incorporation of the deuterated “magic methyl” group can provide profound pharmacological benefits and can be considered as an important tool for drug optimization and development. This review provides a structured overview, according to the trideuteromethylation reagent, of currently established methods for site-selective trideuteromethylations of carbon atoms. Selective introduction of CD2H and CDH2 groups, in addition to CD3, is also considered. For all methods, the corresponding mechanism and scope are discussed whenever reported. As such, this review can be a starting point for synthetic chemists to further advance trideuteromethylation methodologies. At the same time, this review aims to be a guide for medicinal chemists, offering them the available C-CD3 formation strategies for the preparation of new or modified drugs.
dc.description.sponsorshipThe authors acknowledge KAUST for their financial support.
dc.publisherWiley
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/10.1002/chem.202101179
dc.rightsArchived with thanks to Chemistry – A European Journal. © 2021 The Authors. Published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleThe Deuterated “Magic Methyl“ Group - A Guide for Site-selective Trideuteromethyl Incorporation and Labeling using CD3-reagents
dc.typeArticle
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentChemical Science Program
dc.identifier.journalChemistry – A European Journal
dc.eprint.versionPost-print
kaust.personSteverlynck, Joost Andre
kaust.personSitdikov, Ruzal
kaust.personRueping, Magnus
dc.date.accepted2021-06-02
refterms.dateFOA2021-06-03T07:19:28Z
dc.date.published-online2021-07-07
dc.date.published-print2021-08-16


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Archived with thanks to Chemistry – A European Journal. © 2021 The Authors. Published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Except where otherwise noted, this item's license is described as Archived with thanks to Chemistry – A European Journal. © 2021 The Authors. Published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
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