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dc.contributor.authorLiang, Liangliang
dc.contributor.authorYan, Wei
dc.contributor.authorQin, Xian
dc.contributor.authorPeng, Xiao
dc.contributor.authorFeng, Han
dc.contributor.authorWang, Yu
dc.contributor.authorZhu, Ziyu
dc.contributor.authorLiu, Lingmei
dc.contributor.authorHan, Yu
dc.contributor.authorXu, Qinghua
dc.contributor.authorQu, Junle
dc.contributor.authorLiu, Xiaogang
dc.date.accessioned2021-04-14T09:33:04Z
dc.date.available2021-04-14T09:33:04Z
dc.date.issued2019-11-27
dc.identifier.citationLiang, L., Yan, W., Qin, X., Peng, X., Feng, H., Wang, Y., … Liu, X. (2019). Designing Sub-2 nm Organosilica Nanohybrids for Far-Field Super-Resolution Imaging. Angewandte Chemie, 132(2), 756–761. doi:10.1002/ange.201912404
dc.identifier.issn0044-8249
dc.identifier.issn1521-3757
dc.identifier.doi10.1002/ange.201912404
dc.identifier.urihttp://hdl.handle.net/10754/668759
dc.description.abstractStimulated emission depletion (STED) microscopy enables ultrastructural imaging of biological samples with high spatiotemporal resolution. STED nanoprobes based on fluorescent organosilica nanohybrids featuring sub-2 nm size and near-unity quantum yield are presented. The spin–orbit coupling (SOC) of heavy-atom-rich organic fluorophores is mitigated through a silane-molecule-mediated condensation/ dehalogenation process, resulting in bright fluorescent organosilica nanohybrids with multiple emitters in one hybrid nanodot. When harnessed as STED nanoprobes, these fluorescent nanohybrids show intense photoluminescence, high biocompatibility, and long-term photostability. Taking advantage of the low-power excitation (0.5 mW), prolonged singlet-state lifetime, and negligible depletion-induced re-excitation, these STED nanohybrids present high depletion efficiency (> 96%), extremely low saturation intensity (0.54 mW, ca.0.188 MWcm@2), and ultra-high lateral resolution (ca. lem/28).
dc.description.sponsorshipThis work is supported by the Singapore Ministry of Education (MOE2017-T2-2-110), Agency for Science, Technology and Research (A*STAR) (Grant NO. A1883c0011), National Research Foundation, Prime MinisterQs Office, Singapore under its Competitive Research Program (Award No. NRF-CRP15-2015-03) and under the NRF Investigatorship programme (Award No. NRF-NRFI05-2019-0003), the National Key R&D Program of China (2017YFA0700500), the National Natural Science Foundation of China (21771135, 21701119, 61705137, 81727804, 61975127, 31771584),the Science and Technology Project of Shenzhen(KQJSCX20180328093614762). The computational work for this article was supported by resources of the High Performance Computing System at National University of Singapore.
dc.publisherWiley
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1002/ange.201912404
dc.rightsArchived with thanks to Angewandte Chemie
dc.titleDesigning Sub-2 nm Organosilica Nanohybrids for Far-Field Super-Resolution Imaging
dc.typeArticle
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Center
dc.contributor.departmentChemical Science Program
dc.contributor.departmentNanostructured Functional Materials (NFM) laboratory
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.identifier.journalAngewandte Chemie
dc.eprint.versionPost-print
dc.contributor.institutionDepartment of ChemistryNational University of Singapore Singapore 117543 Singapore
dc.contributor.institutionKey Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceCollege of Optoelectronic EngineeringShenzhen University Shenzhen 518060 China
dc.contributor.institutionAdvanced Environmental Biotechnology Centre, Nanyang Environment and Water Research InstituteInterdisciplinary Graduate ProgrammeNanyang Technological University Singapore 637141 Singapore
dc.contributor.institutionSZU-NUS Collaborative Innovation Center for Optoelectronic Science & TechnologyInternational Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of EducationInstitute of Microscale OptoelectronicsShenzhen University Shenzhen 518060 China
dc.contributor.institutionEngineering Technology Research Center for 2D Material Information Function Devices and Systems of Guangdong ProvinceCollege of Optoelectronic EngineeringShenzhen University Shenzhen 518060 China
dc.identifier.volume132
dc.identifier.issue2
dc.identifier.pages756-761
kaust.personLiu, Lingmei
kaust.personHan, Yu


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