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    Cyclic Nucleotide Monophosphates in Plants and Plant Signaling

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    Type
    Book Chapter
    Authors
    Marondedze, Claudius
    Wong, Aloysius Tze cc
    Thomas, Ludivine
    Irving, Helen
    Gehring, Christoph A cc
    KAUST Department
    Biological and Environmental Science and Engineering (BESE) Division
    Bioscience Core Lab
    Bioscience Program
    Computational Bioscience Research Center (CBRC)
    Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division
    Molecular Signalling Group
    Date
    2016-01-01
    Permanent link to this record
    http://hdl.handle.net/10754/668736
    
    Metadata
    Show full item record
    Abstract
    Cyclic nucleotide monophosphates (cNMPs) and the enzymes that can generate them are of increasing interest in the plant sciences. Arguably, the major recent advance came with the release of the complete Arabidopsis thaliana genome that has enabled the systematic search for adenylate (ACs) or guanylate cyclases (GCs) and did eventually lead to the discovery of a number of GCs in higher plants. Many of these proteins have complex domain architectures with AC or GC centers moonlighting within cytosolic kinase domains. Recent reports indicated the presence of not just the canonical cNMPs (i.e., cAMP and cGMP), but also the noncanonical cCMP, cUMP, cIMP, and cdTMP in plant tissues, and this raises several questions. Firstly, what are the functions of these cNMPs, and, secondly, which enzymes can convert the substrate triphosphates into the respective noncanonical cNMPs? The first question is addressed here by comparing the reactive oxygen species (ROS) response of cAMP and cGMP to that elicited by the noncanonical cCMP or cIMP. The results show that particularly cIMP can induce significant ROS production. To answer, at least in part, the second question, we have evaluated homology models of experimentally confirmed plant GCs probing the substrate specificity by molecular docking simulations to determine if they can conceivably catalytically convert substrates other than ATP or GTP. In summary, molecular modeling and substrate docking simulations can contribute to the evaluation of cyclases for noncanonical cyclic mononucleotides and thereby further our understanding of the molecular mechanism that underlie cNMP-dependent signaling in planta.
    Citation
    Marondedze, C., Wong, A., Thomas, L., Irving, H., & Gehring, C. (2015). Cyclic Nucleotide Monophosphates in Plants and Plant Signaling. Handbook of Experimental Pharmacology, 87–103. doi:10.1007/164_2015_35
    Publisher
    Springer Nature
    ISBN
    9783319526713
    9783319526737
    DOI
    10.1007/164_2015_35
    PubMed ID
    26721677
    Additional Links
    https://link.springer.com/chapter/10.1007%2F164_2015_35
    ae974a485f413a2113503eed53cd6c53
    10.1007/164_2015_35
    Scopus Count
    Collections
    Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; Computational Bioscience Research Center (CBRC); Book Chapters; Bioscience Core Lab; Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division

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