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dc.contributor.authorZhu, Huangtianzhi
dc.contributor.authorLi, Qi
dc.contributor.authorKhalil-Cruz, Laila E.
dc.contributor.authorKhashab, Niveen M.
dc.contributor.authorYu, Guocan
dc.contributor.authorHuang, Feihe
dc.date.accessioned2021-04-04T06:05:17Z
dc.date.available2021-04-04T06:05:17Z
dc.date.issued2021-03-23
dc.date.submitted2020-11-04
dc.identifier.citationZhu, H., Li, Q., Khalil-Cruz, L. E., Khashab, N. M., Yu, G., & Huang, F. (2021). Pillararene-based supramolecular systems for theranostics and bioapplications. Science China Chemistry. doi:10.1007/s11426-020-9932-9
dc.identifier.issn1869-1870
dc.identifier.issn1674-7291
dc.identifier.doi10.1007/s11426-020-9932-9
dc.identifier.urihttp://hdl.handle.net/10754/668488
dc.description.abstractAs an emerging type of important macrocycles for supramolecular chemistry, pillararenes and their derivatives have been widely studied and applied in numerous fields, which intensively promotes the development of chemistry, materials science and biology. Pillararene-based theranostic systems are of special interest in the biological and medical areas as they have shown very promising results. Owing to easy preparation, reliable guest affinity, good biocompatibility and stability, pillararenes are frequently used to construct functional biomaterials. On one hand, pillararenes can either be used individually or form diversiform self-assemblies such as micelles, nanoparticles and vesicles to increase water solubility and biocompatibility of drugs. On the other hand, it is promising to modify solid materials like framework materials, silica nanoparticles and graphene oxides with pillararene derivatives to enhance their functions and controllability. In this review, we summarize recent endeavors of pillararene-based supramolecular systems with theranostics and other biological applications comprising drug delivery chemotherapy, photodynamic/photothermal therapy, antimicrobials, bioimaging, etc. By introducing several typical examples, the design principles, preparation strategies, identifications and bio-applications of these pillararene-based supramolecular systems are described. Future challenges and directions of this field are also outlined.
dc.description.sponsorshipThis work was supported by the National Natural Science Foundation of China (22035006). This publication is based in part upon work supported by the King Abdullah University of Science and Technology Office of Sponsored Research (OSR-2019-CRG8-4032).
dc.publisherSpringer Nature
dc.relation.urlhttp://link.springer.com/10.1007/s11426-020-9932-9
dc.rightsArchived with thanks to Science China Chemistry
dc.titlePillararene-based supramolecular systems for theranostics and bioapplications
dc.typeArticle
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Center
dc.contributor.departmentChemical Science Program
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentSmart Hybrid Materials (SHMs) lab
dc.identifier.journalScience China Chemistry
dc.rights.embargodate2022-03-23
dc.eprint.versionPost-print
dc.contributor.institutionState Key Laboratory of Chemical Engineering, Key Laboratory of Excited-State Materials of Zhejiang Province, Department of Chemistry, Zhejiang University, Hangzhou, 310027, China
dc.contributor.institutionGreen Catalysis Center and College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China
kaust.personKhalil-Cruz, Laila E.
kaust.personKhashab, Niveen M.
kaust.grant.numberOSR-2019-CRG8-4032
dc.date.accepted2020-12-29
dc.identifier.eid2-s2.0-85103128290
kaust.acknowledged.supportUnitOSR


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