Pillararene-based supramolecular systems for theranostics and bioapplications
Type
ArticleKAUST Department
Advanced Membranes and Porous Materials Research CenterChemical Science Program
Physical Science and Engineering (PSE) Division
Smart Hybrid Materials (SHMs) lab
KAUST Grant Number
OSR-2019-CRG8-4032Date
2021-03-23Online Publication Date
2021-03-23Print Publication Date
2021-05Embargo End Date
2022-03-23Submitted Date
2020-11-04Permanent link to this record
http://hdl.handle.net/10754/668488
Metadata
Show full item recordAbstract
As an emerging type of important macrocycles for supramolecular chemistry, pillararenes and their derivatives have been widely studied and applied in numerous fields, which intensively promotes the development of chemistry, materials science and biology. Pillararene-based theranostic systems are of special interest in the biological and medical areas as they have shown very promising results. Owing to easy preparation, reliable guest affinity, good biocompatibility and stability, pillararenes are frequently used to construct functional biomaterials. On one hand, pillararenes can either be used individually or form diversiform self-assemblies such as micelles, nanoparticles and vesicles to increase water solubility and biocompatibility of drugs. On the other hand, it is promising to modify solid materials like framework materials, silica nanoparticles and graphene oxides with pillararene derivatives to enhance their functions and controllability. In this review, we summarize recent endeavors of pillararene-based supramolecular systems with theranostics and other biological applications comprising drug delivery chemotherapy, photodynamic/photothermal therapy, antimicrobials, bioimaging, etc. By introducing several typical examples, the design principles, preparation strategies, identifications and bio-applications of these pillararene-based supramolecular systems are described. Future challenges and directions of this field are also outlined.Citation
Zhu, H., Li, Q., Khalil-Cruz, L. E., Khashab, N. M., Yu, G., & Huang, F. (2021). Pillararene-based supramolecular systems for theranostics and bioapplications. Science China Chemistry. doi:10.1007/s11426-020-9932-9Sponsors
This work was supported by the National Natural Science Foundation of China (22035006). This publication is based in part upon work supported by the King Abdullah University of Science and Technology Office of Sponsored Research (OSR-2019-CRG8-4032).Publisher
Springer NatureJournal
Science China ChemistryAdditional Links
http://link.springer.com/10.1007/s11426-020-9932-9ae974a485f413a2113503eed53cd6c53
10.1007/s11426-020-9932-9