Mini-review: Marine natural products and their synthetic analogs as antifouling compounds: 2009–2014
KAUST Grant NumberSA-C0040/UK-C0016
Permanent link to this recordhttp://hdl.handle.net/10754/668400
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AbstractThis review covers 214 marine natural compounds and 23 of their synthetic analogs, which were discovered and/or synthesized from mid-2009 to August 2014. The antifouling (AF) compounds reported have medium to high bioactivity (with a threshold of EC50 < 15.0 mg ml−1). Among these compounds, 82 natural compounds were identified as new structures. All the compounds are marine-derived, demonstrating that marine organisms are prolific and promising sources of natural products that may be developed as environmentally friendly antifoulants. However, this mini-review excludes more than 200 compounds that were also reported as AF compounds but with rather weak bioactivity during the same period. Also excluded are terrestrial-derived AF compounds reported during the last five years. A brief discussion on current challenges in AF compound research is also provided to reflect the authors’ own views in terms of future research directions.
CitationQian, P.-Y., Li, Z., Xu, Y., Li, Y., & Fusetani, N. (2015). Mini-review: Marine natural products and their synthetic analogs as antifouling compounds: 2009–2014. Biofouling, 31(1), 101–122. doi:10.1080/08927014.2014.997226
SponsorsThis work was supported by a grant [DY125-15-T-02] from the China Ocean Mineral Resources Research and Development Association, a grant [SIDSSE-201206] from the Sanya Institute of Deep Sea Science and Engineering, a GRC grant [GRF661611] from Hong Kong Special Administrative Region, and award [SA-C0040/UK-C0016] from King Abdullah University of Science and Technology.
PublisherInforma UK Limited