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dc.contributor.authorHalladjian, Sarkis
dc.contributor.authorKouril, David
dc.contributor.authorMiao, Haichao
dc.contributor.authorGroeller, Eduard
dc.contributor.authorViola, Ivan
dc.contributor.authorIsenberg, Tobias
dc.date.accessioned2021-03-29T11:31:29Z
dc.date.available2021-03-29T11:31:29Z
dc.date.issued2021
dc.identifier.citationHalladjian, S., Kouril, D., Miao, H., Groeller, E., Viola, I., & Isenberg, T. (2021). Multiscale Unfolding: Illustratively Visualizing the Whole Genome at a Glance. IEEE Transactions on Visualization and Computer Graphics, 1–1. doi:10.1109/tvcg.2021.3065443
dc.identifier.issn2160-9306
dc.identifier.doi10.1109/TVCG.2021.3065443
dc.identifier.urihttp://hdl.handle.net/10754/668364
dc.description.abstractWe present Multiscale Unfolding, an interactive technique for illustratively visualizing multiple hierarchical scales of DNA in a single view, showing the genome at different scales and demonstrating how one scale spatially folds into the next. The DNA's extremely long sequential structurearranged differently on several distinct scale levelsis often lost in traditional 3D depictions, mainly due to its multiple levels of dense spatial packing and the resulting occlusion. Furthermore, interactive exploration of this complex structure is cumbersome, requiring visibility management like cut-aways. In contrast to existing temporally controlled multiscale data exploration, we allow viewers to always see and interact with any of the involved scales. For this purpose we separate the depiction into constant-scale and scale transition zones. Constant-scale zones maintain a single-scale representation, while still linearly unfolding the DNA. Inspired by illustration, scale transition zones connect adjacent constant-scale zones via level unfolding, scaling, and transparency. We thus represent the spatial structure of the whole DNA macro-molecule, maintain its local organizational characteristics, linearize its higher-level organization, and use spatially controlled, understandable interpolation between neighboring scales. We also contribute interaction techniques that provide viewers with a coarse-to-fine control for navigating within our all-scales-in-one-view representations and visual aids to illustrate the size differences. Overall, Multiscale Unfolding allows viewers to grasp the DNA's structural composition from chromosomes to the atoms, with increasing levels of "unfoldedness," and can be applied in data-driven illustration and communication.
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)
dc.relation.urlhttps://ieeexplore.ieee.org/document/9376675/
dc.relation.urlhttps://ieeexplore.ieee.org/document/9376675/
dc.relation.urlhttps://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=9376675
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 License.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMultiscale visualization
dc.subjectspatially-controlled scale transition
dc.subjectvisual abstraction
dc.subjectillustrative visualization
dc.subjectgenome
dc.subjectDNA
dc.titleMultiscale Unfolding: Illustratively Visualizing the Whole Genome at a Glance
dc.typeArticle
dc.contributor.departmentComputer Science Program
dc.contributor.departmentComputer, Electrical and Mathematical Science and Engineering (CEMSE) Division
dc.contributor.departmentVisual Computing Center (VCC)
dc.identifier.journalIEEE Transactions on Visualization and Computer Graphics
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionAVIZ, INRIA, Saclay, Ile-de-France, France,
dc.contributor.institutionInstitute of Visual Computing & Human-Centered Technology, TU Wien, 27259 Wien, Wien, Austria, 1040
dc.contributor.institutionInstitute of Computer Graphics and Algorithms, TU Wien, Vienna, Vienna, Austria,
dc.contributor.institutionInstitute of Computer Graphics and Algorithms, Vienna University of Technology, A-1040 Vienna, Austria, Austria, A-1040
dc.identifier.pages1-1
kaust.personViola, Ivan
dc.identifier.eid2-s2.0-85102681209
refterms.dateFOA2021-03-29T11:33:04Z


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