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dc.contributor.authorBarman, Sandra
dc.contributor.authorFager, Cecilia
dc.contributor.authorRöding, Magnus
dc.contributor.authorLorén, Niklas
dc.contributor.authorvon Corswant, Christian
dc.contributor.authorOlsson, Eva
dc.contributor.authorBolin, David
dc.contributor.authorRootzén, Holger
dc.identifier.citationBarman, S., Fager, C., Röding, M., Lorén, N., von Corswant, C., Olsson, E., … Rootzén, H. (2021). New Characterization Measures of Pore Shape and Connectivity Applied to Coatings used for Controlled Drug Release. Journal of Pharmaceutical Sciences. doi:10.1016/j.xphs.2021.02.024
dc.description.abstractPore geometry characterization-methods are important tools for understanding how pore structure influences properties such as transport through a porous material. Bottlenecks can have a large influence on transport and related properties. However, existing methods only catch certain types of bottleneck effects caused by variations in pore size. We here introduce a new measure, geodesic channel strength, which captures a different type of bottleneck effect caused by many paths coinciding in the same pore. We further develop new variants of pore size measures and propose a new way of visualizing 3-D characterization results using layered images. The new measures together with existing measures were used to characterize and visualize properties of 3-D FIB-SEM images of three leached ethyl-cellulose/hydroxypropyl-cellulose films. All films were shown to be anisotropic, and the strongest anisotropy was found in the film with lowest porosity. This film had very tortuous paths and strong geodesic channel-bottlenecks, while the paths through the other two films were relatively straight with well-connected pore networks. The geodesic channel strength was shown to give important new visual and quantitative insights about connectivity, and the new pore size measures provided useful information about anisotropies and inhomogeneities in the pore structures. The methods have been implemented in the freely available software MIST.
dc.description.sponsorshipWe thank Aila Särkkä and everyone involved in the SSF project for valuable feedback. We also appreciate the feedback given at workshops organized by the Chalmers center SuMo Biomaterials and within the project COSIMA, both funded by Vinnova. Funding: This work was supported by the Swedish Foundation for Strategic Research [grant number AM13-0066], the Knut and Alice Wallenberg foundation [grant number 20012.0067], and the Swedish Research Council [grant number 2016-04187].
dc.publisherElsevier BV
dc.rightsThis is an open access article under the CC BY license.
dc.titleNew Characterization Measures of Pore Shape and Connectivity Applied to Coatings used for Controlled Drug Release.
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.identifier.journalJournal of pharmaceutical sciences
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionDepartment of Mathematical Sciences, Chalmers University of Technology and the University of Gothenburg, 412 96 Gothenburg, Sweden.
dc.contributor.institutionDepartment of Physics, Chalmers University of Technology, 412 96 Gothenburg, Sweden.
dc.contributor.institutionAgriculture and Food, RISE Research Institutes of Sweden, Gothenburg, Sweden.
dc.contributor.institutionOral Product Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Gothenburg, Sweden.
kaust.personBolin, David

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