Chemoselective Hydrogenation of Nitroarenes Using an Air-Stable Base-Metal Catalyst
KAUST DepartmentChemical Science Program
KAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Online Publication Date2021-03-23
Print Publication Date2021-04-02
Permanent link to this recordhttp://hdl.handle.net/10754/668219
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AbstractThe reduction of nitroarenes to anilines as well as azobenzenes to hydrazobenzenes using a single base-metal catalyst is reported. The hydrogenation reactions are performed with an air-and moisture-stable manganese catalyst and proceed under relatively mild reaction conditions. The transformation tolerates a broad range of functional groups, affording aniline derivatives and hydrazobenzenes in high yields. Mechanistic studies suggest that the reaction proceeds via a bifunctional activation involving metal–ligand cooperative catalysis.
CitationZubar, V., Dewanji, A., & Rueping, M. (2021). Chemoselective Hydrogenation of Nitroarenes Using an Air-Stable Base-Metal Catalyst. Organic Letters. doi:10.1021/acs.orglett.1c00659
SponsorsWe thank Dr. Jan Sklyaruk for his support in preparing the revision.
PublisherAmerican Chemical Society (ACS)
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/