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dc.contributor.authorAl Massadi, Omar
dc.contributor.authorNogueiras, Ruben
dc.contributor.authorDieguez, Carlos
dc.contributor.authorGirault, Jean-Antoine
dc.date.accessioned2021-03-11T11:05:41Z
dc.date.available2021-03-11T11:05:41Z
dc.date.issued2019-04
dc.identifier.citationAl Massadi, O., Nogueiras, R., Dieguez, C., & Girault, J.-A. (2019). Ghrelin and food reward. Neuropharmacology, 148, 131–138. doi:10.1016/j.neuropharm.2019.01.001
dc.identifier.issn0028-3908
dc.identifier.doi10.1016/j.neuropharm.2019.01.001
dc.identifier.urihttp://hdl.handle.net/10754/668085
dc.description.abstractFood intake is tightly regulated by homeostatic and reward mechanisms and the adequate function of both is necessary for the proper maintenance of energy balance. Ghrelin impacts on these two levels to induce feeding. In this review, we present the actions of ghrelin in food reward, including their dependence on other relevant modulators implicated in the motivational aspects of feeding, including dopamine, opioid peptides, and endocannabinoids. We also describe the interaction between brain areas involved in homeostatic regulation of feeding and the reward system, with a special emphasis on the role of arcuate nucleus melanocortins and lateral hypothalamus orexins in ghrelin function. Finally, we briefly discuss the actions of ghrelin in food reward in obesity. We propose that new insights into the mechanism of action of ghrelin in the rewarding and motivational control of food intake will help to understand food-related disorders including obesity and anorexia.
dc.description.sponsorshipWork in the laboratory of JAG is supported by Inserm, Sorbonne Université (formerly Université Pierre et Marie Curie, UPMC, Paris-6), and grants from ANR MALZ-2013, the King Abdullah University of Science and Technology (KAUST) Office of Sponsored Research award (#OSR-2015-CRG4-2602), Fondation pour la Recherche Médicale and Labex Bio-Psy. Work in the laboratory of RN and CD is supported by grants from MINECO (CD BFU2017-87721 and RN: BFU2015-70664R); Xunta de Galicia (RN: 2015-CP080 and 2016-PG057), and Centro de Investigación Biomédica en Red (CIBER) de Fisiopatología de la Obesidad y Nutrición (CIBERobn). CIBERobn is an initiative of the Instituto de Salud Carlos III (ISCIII) of Spain which is supported by FEDER funds. O.A-M is funded by the ISCIII/SERGAS through a research contract “Sara Borrell” (CD14/00091). The figures were generated by using materials from Servier Medical Art (Servier) under consideration of a Creative Commons Attribution 3.0 Unported License.
dc.publisherElsevier BV
dc.relation.urlhttps://linkinghub.elsevier.com/retrieve/pii/S0028390818306051
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Neuropharmacology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Neuropharmacology, [148, , (2019-04)] DOI: 10.1016/j.neuropharm.2019.01.001 . © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleGhrelin and food reward
dc.typeArticle
dc.identifier.journalNeuropharmacology
dc.eprint.versionPost-print
dc.contributor.institutionInserm UMR-S 839, Paris, 75005, France
dc.contributor.institutionSorbonne Université, Sciences and Engineering Faculty, Paris, 75005, France
dc.contributor.institutionInstitut du Fer a Moulin, Paris, 75005, France
dc.contributor.institutionDepartment of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain
dc.contributor.institutionCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), 15706, Spain
dc.identifier.volume148
dc.identifier.pages131-138
kaust.grant.numberOSR-2015-CRG4-2602
dc.identifier.eid2-s2.0-85060330644
kaust.acknowledged.supportUnitCRG
kaust.acknowledged.supportUnitOffice of Sponsored Research
kaust.acknowledged.supportUnitOSR


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