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    Ghrelin and food reward

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    Type
    Article
    Authors
    Al Massadi, Omar
    Nogueiras, Ruben
    Dieguez, Carlos
    Girault, Jean-Antoine
    KAUST Grant Number
    OSR-2015-CRG4-2602
    Date
    2019-04
    Permanent link to this record
    http://hdl.handle.net/10754/668085
    
    Metadata
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    Abstract
    Food intake is tightly regulated by homeostatic and reward mechanisms and the adequate function of both is necessary for the proper maintenance of energy balance. Ghrelin impacts on these two levels to induce feeding. In this review, we present the actions of ghrelin in food reward, including their dependence on other relevant modulators implicated in the motivational aspects of feeding, including dopamine, opioid peptides, and endocannabinoids. We also describe the interaction between brain areas involved in homeostatic regulation of feeding and the reward system, with a special emphasis on the role of arcuate nucleus melanocortins and lateral hypothalamus orexins in ghrelin function. Finally, we briefly discuss the actions of ghrelin in food reward in obesity. We propose that new insights into the mechanism of action of ghrelin in the rewarding and motivational control of food intake will help to understand food-related disorders including obesity and anorexia.
    Citation
    Al Massadi, O., Nogueiras, R., Dieguez, C., & Girault, J.-A. (2019). Ghrelin and food reward. Neuropharmacology, 148, 131–138. doi:10.1016/j.neuropharm.2019.01.001
    Sponsors
    Work in the laboratory of JAG is supported by Inserm, Sorbonne Université (formerly Université Pierre et Marie Curie, UPMC, Paris-6), and grants from ANR MALZ-2013, the King Abdullah University of Science and Technology (KAUST) Office of Sponsored Research award (#OSR-2015-CRG4-2602), Fondation pour la Recherche Médicale and Labex Bio-Psy. Work in the laboratory of RN and CD is supported by grants from MINECO (CD BFU2017-87721 and RN: BFU2015-70664R); Xunta de Galicia (RN: 2015-CP080 and 2016-PG057), and Centro de Investigación Biomédica en Red (CIBER) de Fisiopatología de la Obesidad y Nutrición (CIBERobn). CIBERobn is an initiative of the Instituto de Salud Carlos III (ISCIII) of Spain which is supported by FEDER funds. O.A-M is funded by the ISCIII/SERGAS through a research contract “Sara Borrell” (CD14/00091). The figures were generated by using materials from Servier Medical Art (Servier) under consideration of a Creative Commons Attribution 3.0 Unported License.
    Publisher
    Elsevier BV
    Journal
    Neuropharmacology
    DOI
    10.1016/j.neuropharm.2019.01.001
    Additional Links
    https://linkinghub.elsevier.com/retrieve/pii/S0028390818306051
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.neuropharm.2019.01.001
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