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dc.contributor.authorGasperini, Danila
dc.contributor.authorGreenhalgh, Mark D.
dc.contributor.authorImad, Rehan
dc.contributor.authorSiddiqui, Shezaib
dc.contributor.authorMalik, Anum
dc.contributor.authorArshad, Fizza
dc.contributor.authorChoudhary, Muhammad Iqbal
dc.contributor.authorAl-Majid, Abdullah M.
dc.contributor.authorCordes, David B.
dc.contributor.authorSlawin, Alexandra M. Z.
dc.contributor.authorNolan, Steven P.
dc.contributor.authorSmith, Andrew D.
dc.date.accessioned2021-03-10T11:50:28Z
dc.date.available2021-03-10T11:50:28Z
dc.date.issued2018-12-21
dc.identifier.citationGasperini, D., Greenhalgh, M. D., Imad, R., Siddiqui, S., Malik, A., Arshad, F., … Smith, A. D. (2018). Chiral AuI - and AuIII -Isothiourea Complexes: Synthesis, Characterization and Application. Chemistry - A European Journal, 25(4), 1064–1075. doi:10.1002/chem.201804653
dc.identifier.issn0947-6539
dc.identifier.doi10.1002/chem.201804653
dc.identifier.urihttp://hdl.handle.net/10754/668045
dc.description.abstractDuring an investigation into the potential union of Lewis basic isothiourea organocatalysis and gold catalysis, the formation of gold-isothiourea complexes was observed. These novel gold complexes were formed in high yield and were found to be air- and moisture stable. A series of neutral and cationic chiral gold(I) and gold(III) complexes bearing enantiopure isothiourea ligands was therefore synthesized and fully characterized. The steric and electronic properties of the isothiourea ligands was assessed through calculation of their percent buried volume and the synthesis and analysis of novel iridium(I)-isothiourea carbonyl complexes. The novel gold(I)- and gold(III)-isothiourea complexes have been applied in preliminary catalytic and biological studies, and display promising preliminary levels of catalytic activity and potency towards cancerous cell lines and clinically relevant enzymes.
dc.description.sponsorshipA.D.S. thanks the Royal Society for a Wolfson Research Merit Award. We also thank the EPSRC UK National Mass Spectrometry Facility at Swansea University. S.P.N. thanks King Abdullah University of Science and Technology (Award No. OSR-2015-CCF-1974-03) and King Saud University for support via its DSFP program.
dc.publisherWiley
dc.relation.urlhttp://doi.wiley.com/10.1002/chem.201804653
dc.rightsArchived with thanks to Chemistry - A European Journal
dc.titleChiral AuI - and AuIII -Isothiourea Complexes: Synthesis, Characterization and Application
dc.typeArticle
dc.identifier.journalChemistry - A European Journal
dc.eprint.versionPost-print
dc.contributor.institutionEaStCHEM; School of Chemistry; University of St Andrews; St Andrews Fife KY16 9ST UK
dc.contributor.institutionH.E.J Research Institute of Chemistry; International Center for Chemical and Biological Sciences; University of Karachi; Karachi 75270 Pakistan
dc.contributor.institutionDepartment of Biochemistry; Faculty of Science; King Abdulaziz University; Jeddah 21412 Saudi Arabia
dc.contributor.institutionDepartment of Chemistry and Center for Sustainable Chemistry; King Saud University; P.O. Box 2455 Riyadh 11451 Saudi Arabia
dc.contributor.institutionChemistry Department, College of Science; Ghent University; Krijgslaan 281 9000 Ghent Belgium
dc.identifier.volume25
dc.identifier.issue4
dc.identifier.pages1064-1075
kaust.grant.numberOSR-2015-CCF-1974-03
dc.identifier.eid2-s2.0-85059011049
kaust.acknowledged.supportUnitOSR


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