Chiral AuI

  • and AuIII -Isothiourea Complexes: Synthesis, Characterization and Application

Abstract
During an investigation into the potential union of Lewis basic isothiourea organocatalysis and gold catalysis, the formation of gold-isothiourea complexes was observed. These novel gold complexes were formed in high yield and were found to be air- and moisture stable. A series of neutral and cationic chiral gold(I) and gold(III) complexes bearing enantiopure isothiourea ligands was therefore synthesized and fully characterized. The steric and electronic properties of the isothiourea ligands was assessed through calculation of their percent buried volume and the synthesis and analysis of novel iridium(I)-isothiourea carbonyl complexes. The novel gold(I)- and gold(III)-isothiourea complexes have been applied in preliminary catalytic and biological studies, and display promising preliminary levels of catalytic activity and potency towards cancerous cell lines and clinically relevant enzymes.

Citation
Gasperini, D., Greenhalgh, M. D., Imad, R., Siddiqui, S., Malik, A., Arshad, F., … Smith, A. D. (2018). Chiral AuI

  • and AuIII -Isothiourea Complexes: Synthesis, Characterization and Application. Chemistry - A European Journal, 25(4), 1064–1075. doi:10.1002/chem.201804653

    Acknowledgements
    A.D.S. thanks the Royal Society for a Wolfson Research Merit Award. We also thank the EPSRC UK National Mass Spectrometry Facility at Swansea University. S.P.N. thanks King Abdullah University of Science and Technology (Award No. OSR-2015-CCF-1974-03) and King Saud University for support via its DSFP program.

    Publisher
    Wiley

    Journal
    Chemistry - A European Journal

    DOI
    10.1002/chem.201804653

    Additional Links
    http://doi.wiley.com/10.1002/chem.201804653
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