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dc.contributor.authorBadshah, Syed Lal
dc.contributor.authorRiaz, Anila
dc.contributor.authorMuhammad, Akhtar
dc.contributor.authorTel Çayan, Gülsen Tel
dc.contributor.authorÇayan, Fatih
dc.contributor.authorEmin Duru, Mehmet Emin
dc.contributor.authorAhmad, Nasir
dc.contributor.authorEmwas, Abdul-Hamid M.
dc.contributor.authorJaremko, Mariusz
dc.date.accessioned2021-03-09T07:59:39Z
dc.date.available2021-03-09T07:59:39Z
dc.date.issued2021-03-08
dc.date.submitted2021-01-30
dc.identifier.citationBadshah, S. L., Riaz, A., Muhammad, A., Tel Çayan, G. T., Çayan, F., Emin Duru, M. E., … Jaremko, M. (2021). Isolation, Characterization, and Medicinal Potential of Polysaccharides of Morchella esculenta. Molecules, 26(5), 1459. doi:10.3390/molecules26051459
dc.identifier.issn1420-3049
dc.identifier.doi10.3390/molecules26051459
dc.identifier.urihttp://hdl.handle.net/10754/667988
dc.description.abstractMushroom polysaccharides are active medicinal compounds that possess immune-modulatory and anticancer properties. Currently, the mushroom polysaccharides krestin, lentinan, and polysaccharopeptides are used as anticancer drugs. They are an unexplored source of natural products with huge potential in both the medicinal and nutraceutical industries. The northern parts of Pakistan have a rich biodiversity of mushrooms that grow during different seasons of the year. Here we selected an edible Morchella esculenta (true morels) of the Ascomycota group for polysaccharide isolation and characterization. Polysaccharopeptides and polysaccharides from this mushroom were isolated using the green chemistry, hot water treatment method. Fourier transform infrared spectroscopy revealed the sugar nature and possible beta-glucan type structure of these polysaccharides. Antioxidant assays showed that the deproteinized polysaccharides have moderate free radical scavenging activity. These isolated polysaccharides exhibited good acetylcholinesterase (AChE) and butyryl cholinesterase (BChE) inhibition activities. Therefore, these polysaccharides may be valuable for the treatment of Alzheimer’s and Parkinson’s diseases. Further bioassays are needed to discover the true potential of M. esculenta polysaccharides for medicinal purposes.
dc.description.sponsorshipWe appreciate King Abdullah University of Science and Technology, Saudi Arabia for their support.
dc.publisherMDPI AG
dc.relation.urlhttps://www.mdpi.com/1420-3049/26/5/1459
dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleIsolation, Characterization, and Medicinal Potential of Polysaccharides of Morchella esculenta
dc.typeArticle
dc.contributor.departmentNMR
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.identifier.journalMolecules
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionDepartment of Chemistry, Islamia College University Peshawar, Peshawar 25120, Pakistan.
dc.contributor.institutionDepartment of Chemistry and Chemical Processing Technologies, Muğla Vocational School, Muğla Sıtkı Koçman University, 48000 Muğla, Turkey.
dc.identifier.volume26
dc.identifier.issue5
dc.identifier.pages1459
kaust.personEmwas, Abdul-Hamid M.
kaust.personJaremko, Mariusz
dc.date.accepted2021-03-04
refterms.dateFOA2021-03-09T08:00:10Z


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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
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