Isolation, Characterization, and Medicinal Potential of Polysaccharides of Morchella esculenta
Type
ArticleAuthors
Badshah, Syed Lal
Riaz, Anila
Muhammad, Akhtar
Tel Çayan, Gülsen Tel
Çayan, Fatih
Emin Duru, Mehmet Emin
Ahmad, Nasir
Emwas, Abdul-Hamid M.

Jaremko, Mariusz

KAUST Department
Biological and Environmental Science and Engineering (BESE) DivisionBioscience Program
NMR
Date
2021-03-08Submitted Date
2021-01-30Permanent link to this record
http://hdl.handle.net/10754/667988
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Show full item recordAbstract
Mushroom polysaccharides are active medicinal compounds that possess immune-modulatory and anticancer properties. Currently, the mushroom polysaccharides krestin, lentinan, and polysaccharopeptides are used as anticancer drugs. They are an unexplored source of natural products with huge potential in both the medicinal and nutraceutical industries. The northern parts of Pakistan have a rich biodiversity of mushrooms that grow during different seasons of the year. Here we selected an edible Morchella esculenta (true morels) of the Ascomycota group for polysaccharide isolation and characterization. Polysaccharopeptides and polysaccharides from this mushroom were isolated using the green chemistry, hot water treatment method. Fourier transform infrared spectroscopy revealed the sugar nature and possible beta-glucan type structure of these polysaccharides. Antioxidant assays showed that the deproteinized polysaccharides have moderate free radical scavenging activity. These isolated polysaccharides exhibited good acetylcholinesterase (AChE) and butyryl cholinesterase (BChE) inhibition activities. Therefore, these polysaccharides may be valuable for the treatment of Alzheimer’s and Parkinson’s diseases. Further bioassays are needed to discover the true potential of M. esculenta polysaccharides for medicinal purposes.Citation
Badshah, S. L., Riaz, A., Muhammad, A., Tel Çayan, G. T., Çayan, F., Emin Duru, M. E., … Jaremko, M. (2021). Isolation, Characterization, and Medicinal Potential of Polysaccharides of Morchella esculenta. Molecules, 26(5), 1459. doi:10.3390/molecules26051459Sponsors
We appreciate King Abdullah University of Science and Technology, Saudi Arabia for their support.Publisher
MDPI AGJournal
MoleculesAdditional Links
https://www.mdpi.com/1420-3049/26/5/1459ae974a485f413a2113503eed53cd6c53
10.3390/molecules26051459
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