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dc.contributor.authorHerrera-Lopez, Gabriel
dc.contributor.authorLemtiri-Chlieh, Fouad
dc.contributor.authorMahmood, Hanan S.
dc.contributor.authorMottier, Lorene
dc.contributor.authorFiumelli, Hubert
dc.contributor.authorMagistretti, Pierre J.
dc.date.accessioned2021-03-08T08:19:51Z
dc.date.available2021-03-08T08:19:51Z
dc.date.issued2019-09
dc.identifier.citationHerrera-Lopez, G., Lemtiri-Chlieh, F., Mahmood, H., Mottier, L., Fiumelli, H., & Magistretti, P. J. (2019). Lactate enhances NMDA receptor responses via two distinct mechanisms. IBRO Reports, 6, S397–S398. doi:10.1016/j.ibror.2019.07.1264
dc.identifier.issn2451-8301
dc.identifier.doi10.1016/j.ibror.2019.07.1264
dc.identifier.urihttp://hdl.handle.net/10754/667965
dc.description.abstractLactate is known as an energy substrate for neurons. It is also emerging as a trophic signaling molecule regulating higher brain functions such as learning and memory. Lactate was shown to potentiate NMDA receptor signaling and regulate gene expression related to synaptic plasticity. Using patch-clamp recordings in cultured cortical neurons, we found that lactate enhanced amplitude and inactivation time-constant (tau) of NMDA receptor currents (INMDA) evoked by brief applications of glutamate and glycine. The effect on the amplitude was prevented by pre-treating neurons with a MCTs blocker or by including CaMKII inhibitors in the patch pipette, whereas the effect on tau was not.
dc.publisherElsevier BV
dc.relation.urlhttps://linkinghub.elsevier.com/retrieve/pii/S2451830119313160
dc.rightsThis article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed. For commercial reuse, permission must be requested below.
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleLactate enhances NMDA receptor responses via two distinct mechanisms
dc.typeArticle
dc.contributor.departmentBioscience Program
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.identifier.journalIBRO Reports
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionCinvestav-IPN, Mexico City, Mexico.
dc.contributor.institutionDepartment of Neuroscience, UConn Health, Farmington, USA.
dc.identifier.volume6
dc.identifier.pagesS397-S398
kaust.personMahmood, Hanan
kaust.personMottier, Lorene
kaust.personFiumelli, Hubert
kaust.personMagistretti, Pierre J.
refterms.dateFOA2021-03-08T08:20:27Z


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This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.
For commercial reuse, permission must be requested below.
Except where otherwise noted, this item's license is described as This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed. For commercial reuse, permission must be requested below.