Lactate enhances NMDA receptor responses via two distinct mechanisms

Lactate is known as an energy substrate for neurons. It is also emerging as a trophic signaling molecule regulating higher brain functions such as learning and memory. Lactate was shown to potentiate NMDA receptor signaling and regulate gene expression related to synaptic plasticity. Using patch-clamp recordings in cultured cortical neurons, we found that lactate enhanced amplitude and inactivation time-constant (tau) of NMDA receptor currents (INMDA) evoked by brief applications of glutamate and glycine. The effect on the amplitude was prevented by pre-treating neurons with a MCTs blocker or by including CaMKII inhibitors in the patch pipette, whereas the effect on tau was not.

Herrera-Lopez, G., Lemtiri-Chlieh, F., Mahmood, H., Mottier, L., Fiumelli, H., & Magistretti, P. J. (2019). Lactate enhances NMDA receptor responses via two distinct mechanisms. IBRO Reports, 6, S397–S398. doi:10.1016/j.ibror.2019.07.1264

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IBRO Reports


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