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    Molecular pathogenesis of malaria

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    Type
    Book Chapter
    Authors
    Roberts, David J.
    Pain, Arnab cc
    Chitnis, Chetan E.
    KAUST Department
    Biological and Environmental Science and Engineering (BESE) Division
    Bioscience Program
    Pathogen Genomics Laboratory
    Date
    2019-09-20
    Permanent link to this record
    http://hdl.handle.net/10754/667776
    
    Metadata
    Show full item record
    Abstract
    This chapter examines the basic features of malaria the parasite and malaria the disease, the molecular aspects of the invasion of red blood cells, and the adhesion of infected red blood cells to host cells and receptors and their role in pathogenesis. It considers the pathology of anemia, which is a prominent feature of the disease, and outlines drug treatment and vaccine development for malaria, as well as genomic approaches to the study of the parasite, pathology, and prevention of the disease. The malarial parasite has a complex life cycle, alternating between humans and the female Anopheles mosquito, a liver and blood stage of growth, complex eukaryotic metabolic systems, and a panoply of mechanisms to evade protective host responses. The invasion of erythrocytes by malaria parasites is a complex process and requires many specific molecular interactions. The anemia of Plasmodium falciparum malaria is typically normocytic and normochromic, with a notable absence of reticulocytes.
    Citation
    Roberts, D. J., Pain, A., & Chitnis, C. E. (2019). Molecular pathogenesis of malaria. Molecular Hematology 4e, 193–206. doi:10.1002/9781119252863.ch15
    Publisher
    Wiley
    ISBN
    9781119252863
    DOI
    10.1002/9781119252863.ch15
    Additional Links
    https://onlinelibrary.wiley.com/doi/abs/10.1002/9781119252863.ch15
    ae974a485f413a2113503eed53cd6c53
    10.1002/9781119252863.ch15
    Scopus Count
    Collections
    Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; Book Chapters

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