Type
Book ChapterKAUST Department
Biological and Environmental Science and Engineering (BESE) DivisionBioscience Program
Pathogen Genomics Laboratory
Date
2019-09-20Permanent link to this record
http://hdl.handle.net/10754/667776
Metadata
Show full item recordAbstract
This chapter examines the basic features of malaria the parasite and malaria the disease, the molecular aspects of the invasion of red blood cells, and the adhesion of infected red blood cells to host cells and receptors and their role in pathogenesis. It considers the pathology of anemia, which is a prominent feature of the disease, and outlines drug treatment and vaccine development for malaria, as well as genomic approaches to the study of the parasite, pathology, and prevention of the disease. The malarial parasite has a complex life cycle, alternating between humans and the female Anopheles mosquito, a liver and blood stage of growth, complex eukaryotic metabolic systems, and a panoply of mechanisms to evade protective host responses. The invasion of erythrocytes by malaria parasites is a complex process and requires many specific molecular interactions. The anemia of Plasmodium falciparum malaria is typically normocytic and normochromic, with a notable absence of reticulocytes.Citation
Roberts, D. J., Pain, A., & Chitnis, C. E. (2019). Molecular pathogenesis of malaria. Molecular Hematology 4e, 193–206. doi:10.1002/9781119252863.ch15Publisher
WileyISBN
9781119252863Additional Links
https://onlinelibrary.wiley.com/doi/abs/10.1002/9781119252863.ch15ae974a485f413a2113503eed53cd6c53
10.1002/9781119252863.ch15