An all-solid-state heterojunction oxide transistor for the rapid detection of biomolecules and SARS-CoV-2 spike S1 protein
Alghamdi, Wejdan S.
Mottram, Alexander D.
Anthopoulos, Thomas D.
KAUST DepartmentKAUST Solar Center (KSC)
King Abdullah University of Science and Technology (KAUST), KAUST Solar Centre, Thuwal 23955-6900, Saudi Arabia.
Material Science and Engineering Program
Material Science and Engineering
Physical Science and Engineering (PSE) Division
Permanent link to this recordhttp://hdl.handle.net/10754/667748
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AbstractSolid-state transistor sensors that can detect biomolecules in real time are highly attractive for emerging bioanalytical applications. However, combining cost-effective manufacturing with high sensitivity, specificity and fast sensing response, remains challenging. Here we develop low-temperature solution-processed In2O3/ZnO heterojunction transistors featuring a geometrically engineered tri-channel architecture for rapid real-time detection of different biomolecules. The sensor combines a high electron mobility channel, attributed to the quasi-two-dimensional electron gas (q2DEG) at the buried In2O3/ZnO heterointerface, in close proximity to a sensing surface featuring tethered analyte receptors. The unusual tri-channel design enables strong coupling between the buried q2DEG and the minute electronic perturbations occurring during receptor-analyte interactions allowing for robust, real-time detection of biomolecules down to attomolar (aM) concentrations. By functionalizing the tri-channel surface with SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) antibody receptors, we demonstrate real-time detection of the SARS-CoV-2 spike S1 protein down to attomolar concentrations in under two minutes.
CitationLin, Y.-H., Han, Y., Sharma, A., AlGhamdi, W. S., Liu, C.-H., Chang, T.-H., … Anthopoulos, T. D. (2021). An all-solid-state heterojunction oxide transistor for the rapid detection of biomolecules and SARS-CoV-2 spike S1 protein. doi:10.1101/2021.01.19.427256
PublisherCold Spring Harbor Laboratory