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dc.contributor.authorGhosh, Shreya
dc.contributor.authorPerfield II, James W.
dc.contributor.authorSaikaly, Pascal
dc.contributor.authorOerther, Daniel B.
dc.date.accessioned2021-02-28T11:56:29Z
dc.date.available2021-02-28T11:56:29Z
dc.date.issued2012-04
dc.identifier.citationGhosh, S., Perfield, J. W., Saikaly, P. E., & Oerther, D. B. (2012). Comparison of sterculic oil induced changes in the gut microbiota of lean and obese mice. The FASEB Journal, 26(S1). doi:10.1096/fasebj.26.1_supplement.830.2
dc.identifier.doi10.1096/fasebj.26.1_supplement.830.2
dc.identifier.urihttp://hdl.handle.net/10754/667713
dc.description.abstractRecent obesity research has reported differences in intestinal microbiota between obese ob/ob mice and lean wild type mice suggesting a potential link between bacterial populations and metabolic health. Sterculic oil (SO) is a natural inhibitor of stearoyl-CoA desaturase-1, a potential therapeutic target for the treatment/attenuation of obesity and insulin resistance. The aim of this study was to investigate the response of the obese and lean gut microbiota to a SO supplemented diet. Five-week old male lean (WT) and obese (ob/ob) mice were fed either a control AIN-93G diet or an AIN-93G diet containing 0.5% SO for 9 weeks Barcoded pyrosequencing of the V4-V5 region of the 16S rRNA gene was employed to characterize cecal microbiota. Intestinal microbiota from WT mice fed a control diet were more diverse, although there were no significant differences in the proportions of major phyla from WT and ob/ob mice. Irrespective of genotype, SO was negatively correlated with the relative abundances of Actinobacteria, Bacilli and Erysipelotrichi. This shift was not associated with a change in body weight, however a statistically significant improvement in glucose tolerance and insulin sensitivity was observed in the ob/ob mice fed SO. In our study, diet had a greater impact on gut microbiota as compared to genotype and these changes were associated with an improved metabolic health.
dc.description.sponsorshipGrant Funding Source : Missouri University of Science and Technology
dc.publisherFederation of American Societies for Experimental Biology (FASEB)
dc.relation.urlhttps://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.26.1_supplement.830.2
dc.rightsArchived with thanks to Federation of American Societies for Experimental Biology (FASEB)
dc.titleComparison of sterculic oil induced changes in the gut microbiota of lean and obese mice
dc.typePresentation
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentEnvironmental Biotechnology Research Group
dc.contributor.departmentEnvironmental Science and Engineering Program
dc.contributor.departmentWater Desalination and Reuse Research Center (WDRC)
dc.conference.dateApril 2012
dc.conference.nameExperimental Biology 2012 Meeting
dc.eprint.versionPost-print
dc.contributor.institutionMissouri University of Science and Technology, Rolla, MO
dc.contributor.institutionUniversity of Missouri, Columbia, MO
pubs.publication-statusPublished
kaust.personSaikaly, Pascal
refterms.dateFOA2021-02-28T11:56:29Z


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