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    Comparison of sterculic oil induced changes in the gut microbiota of lean and obese mice

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    Type
    Presentation
    Authors
    Ghosh, Shreya
    Perfield II, James W.
    Saikaly, Pascal cc
    Oerther, Daniel B.
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Environmental Science and Engineering Program
    Water Desalination and Reuse Research Center (WDRC)
    Date
    2012-04
    Permanent link to this record
    http://hdl.handle.net/10754/667713
    
    Metadata
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    Abstract
    Recent obesity research has reported differences in intestinal microbiota between obese ob/ob mice and lean wild type mice suggesting a potential link between bacterial populations and metabolic health. Sterculic oil (SO) is a natural inhibitor of stearoyl-CoA desaturase-1, a potential therapeutic target for the treatment/attenuation of obesity and insulin resistance. The aim of this study was to investigate the response of the obese and lean gut microbiota to a SO supplemented diet. Five-week old male lean (WT) and obese (ob/ob) mice were fed either a control AIN-93G diet or an AIN-93G diet containing 0.5% SO for 9 weeks Barcoded pyrosequencing of the V4-V5 region of the 16S rRNA gene was employed to characterize cecal microbiota. Intestinal microbiota from WT mice fed a control diet were more diverse, although there were no significant differences in the proportions of major phyla from WT and ob/ob mice. Irrespective of genotype, SO was negatively correlated with the relative abundances of Actinobacteria, Bacilli and Erysipelotrichi. This shift was not associated with a change in body weight, however a statistically significant improvement in glucose tolerance and insulin sensitivity was observed in the ob/ob mice fed SO. In our study, diet had a greater impact on gut microbiota as compared to genotype and these changes were associated with an improved metabolic health.
    Sponsors
    Grant Funding Source : Missouri University of Science and Technology
    Publisher
    Federation of American Societies for Experimental Biology (FASEB)
    Conference/Event name
    Experimental Biology 2012 Meeting
    DOI
    10.1096/fasebj.26.1_supplement.830.2
    Additional Links
    https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.26.1_supplement.830.2
    ae974a485f413a2113503eed53cd6c53
    10.1096/fasebj.26.1_supplement.830.2
    Scopus Count
    Collections
    Biological and Environmental Sciences and Engineering (BESE) Division; Environmental Science and Engineering Program; Water Desalination and Reuse Research Center (WDRC); Presentations

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