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    Gold nanostructured laser-scribed graphene: A new electrochemical biosensing platform for potential point-of-care testing of disease biomarkers

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    Gold_1-s2.0-S0956566321001536-main.pdf
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    1.079Mb
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    PDF
    Description:
    Accepted manuscript
    Embargo End Date:
    2023-02-01
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    Type
    Article
    Authors
    Rauf, Sakandar cc
    Lahcen, Abdellatif Ait
    Aljedaibi, Abdulrahman
    Beduk, Tutku
    Ilton de Oliveira Filho, José
    Salama, Khaled N. cc
    KAUST Department
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Electrical Engineering
    Electrical Engineering Program
    Material Science and Engineering Program
    Physical Science and Engineering (PSE) Division
    Sensors Lab
    Sensors Lab, Advanced Membranes & Porous Materials Centre (AMPMC). Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.
    Date
    2021-02
    Embargo End Date
    2023-02-01
    Submitted Date
    2020-11-17
    Permanent link to this record
    http://hdl.handle.net/10754/667684
    
    Metadata
    Show full item record
    Abstract
    Improvements in the Laser-scribed graphene (LSG)-based electrodes are critical to overcoming limitations of bare LSG electrodes in terms of sensitivity, direct immobilization of detection probes for biosensor fabrication, and ease of integration with point-of-care (POC) devices. Herein, we introduce a new class of nanostructured gold modified LSG (LSG-AuNS) electrochemical sensing system comprising LSG-AuNS working electrode, LSG reference, and LSG counter electrode. LSG-AuNS electrodes are realized by electrodeposition of gold chloride (HAuCl4) solution, which gave ∼2-fold enhancement in sensitivity and electrocatalytic activity compared to bare LSG electrode and commercially available screen-printed gold electrode (SPAuE). We demonstrate LSG-AuNS electrochemical aptasensor for detecting human epidermal growth factor receptor 2 (Her-2) with a limit of detection (LOD) of 0.008 ng/mL and a linear range of 0.1-200 ng/mL. LSG-AuNS-aptasensor can easily detect different concentrations of Her-2 spiked in undiluted human serum. Finally, to show the LSG-AuNS sensor system's potential to develop POC biosensor devices, we integrated LSG-AuNS electrodes with a handheld electrochemical system operated using a custom-developed mobile application.
    Citation
    Rauf, S., Lahcen, A. A., Aljedaibi, A., Beduk, T., Ilton de Oliveira Filho, J., & Salama, K. N. (2021). Gold nanostructured laser-scribed graphene: A new electrochemical biosensing platform for potential point-of-care testing of disease biomarkers. Biosensors and Bioelectronics, 113116. doi:10.1016/j.bios.2021.113116
    Sponsors
    The authors would like to express their acknowledgements to the financial support of funding from King Abdullah University of Science and Technology (KAUST), Saudi Arabia. Also, we thank the KAUST Sensor Initiative and KAUST visiting student program for supporting this work.
    Publisher
    Elsevier BV
    Journal
    Biosensors and Bioelectronics
    DOI
    10.1016/j.bios.2021.113116
    Additional Links
    https://linkinghub.elsevier.com/retrieve/pii/S0956566321001536
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.bios.2021.113116
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division; Electrical Engineering Program; Material Science and Engineering Program; Sensors Lab; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

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