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dc.contributor.authorLan, Yi
dc.contributor.authorSun, Jin
dc.contributor.authorChen, Chong
dc.contributor.authorSun, Yanan
dc.contributor.authorZhou, Yadong
dc.contributor.authorYang, Yi
dc.contributor.authorZhang, Weipeng
dc.contributor.authorLi, Runsheng
dc.contributor.authorZhou, Kun
dc.contributor.authorWong, Wai Chuen
dc.contributor.authorKwan, Yick Hang
dc.contributor.authorCheng, Aifang
dc.contributor.authorBougouffa, Salim
dc.contributor.authorVan Dover, Cindy Lee
dc.contributor.authorQiu, Jian-Wen
dc.contributor.authorQian, Pei-Yuan
dc.date.accessioned2021-02-22T05:59:21Z
dc.date.available2021-02-22T05:59:21Z
dc.date.issued2021-02-20
dc.date.submitted2020-05-04
dc.identifier.citationLan, Y., Sun, J., Chen, C., Sun, Y., Zhou, Y., Yang, Y., … Qian, P.-Y. (2021). Hologenome analysis reveals dual symbiosis in the deep-sea hydrothermal vent snail Gigantopelta aegis. Nature Communications, 12(1). doi:10.1038/s41467-021-21450-7
dc.identifier.issn2041-1723
dc.identifier.pmid33608555
dc.identifier.doi10.1038/s41467-021-21450-7
dc.identifier.urihttp://hdl.handle.net/10754/667538
dc.description.abstractAnimals endemic to deep-sea hydrothermal vents often form obligatory symbioses with bacteria, maintained by intricate host-symbiont interactions. Most genomic studies on holobionts have not investigated both sides to similar depths. Here, we report dual symbiosis in the peltospirid snail Gigantopelta aegis with two gammaproteobacterial endosymbionts: a sulfur oxidiser and a methane oxidiser. We assemble high-quality genomes for all three parties, including a chromosome-level host genome. Hologenomic analyses reveal mutualism with nutritional complementarity and metabolic co-dependency, highly versatile in transporting and using chemical energy. Gigantopelta aegis likely remodels its immune system to facilitate dual symbiosis. Comparisons with Chrysomallon squamiferum, a confamilial snail with a single sulfur-oxidising gammaproteobacterial endosymbiont, show that their sulfur-oxidising endosymbionts are phylogenetically distant. This is consistent with previous findings that they evolved endosymbiosis convergently. Notably, the two sulfur-oxidisers share the same capabilities in biosynthesising nutrients lacking in the host genomes, potentially a key criterion in symbiont selection.
dc.description.sponsorshipWe thank the captain and crew of the R/V Xiangyanghong 9 and pilots of HOV Jiaolong for their great support during the research cruise DY35th-II, the captain and crew of the R/V Dayang Yihao as well as the operation team of the ROV Sea Dragon III during the third leg of the China Ocean Mineral Resources Research and Development Association DY52nd cruise. Dr. Jack C.H. Ip and Dr. Ting Xu from Hong Kong Baptist University, as well as Dr. Ken Takai and Dr. Shinsuke Kawagucci from JAMSTEC are gratefully acknowledged for their helpful comments. Katsuyuki Uematsu (Marine Works Japan Ltd.) is thanked for his help during the TEM observations. This work was supported by grants from the National Key R&D Program of China (2018YFC0309904), China Ocean Mineral Resources Research and Development Association (DY135-E2-1-03), the Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) (SMSEGL20SC01), Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) (GML2019ZD0409), and Major Project of Basic and Applied Basic Research of Guangdong Province (2019B030302004-04).
dc.publisherSpringer Science and Business Media LLC
dc.relation.urlhttp://www.nature.com/articles/s41467-021-21450-7
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleHologenome analysis reveals dual symbiosis in the deep-sea hydrothermal vent snail Gigantopelta aegis.
dc.typeArticle
dc.contributor.departmentBioinformatics
dc.identifier.journalNature communications
dc.eprint.versionPublisher's Version/PDF
dc.identifier.volume12
dc.identifier.issue1
kaust.personBougouffa, Salim
kaust.personBougouffa, Salim
dc.date.accepted2021-01-07
refterms.dateFOA2021-02-22T05:59:56Z


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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
Except where otherwise noted, this item's license is described as This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.