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dc.contributor.authorEscartin, Carole
dc.contributor.authorGalea, Elena
dc.contributor.authorLakatos, András
dc.contributor.authorO'Callaghan, James P
dc.contributor.authorPetzold, Gabor C
dc.contributor.authorSerrano-Pozo, Alberto
dc.contributor.authorSteinhäuser, Christian
dc.contributor.authorVolterra, Andrea
dc.contributor.authorCarmignoto, Giorgio
dc.contributor.authorAgarwal, Amit
dc.contributor.authorAllen, Nicola J
dc.contributor.authorAraque, Alfonso
dc.contributor.authorBarbeito, Luis
dc.contributor.authorBarzilai, Ari
dc.contributor.authorBergles, Dwight E
dc.contributor.authorBonvento, Gilles
dc.contributor.authorButt, Arthur M
dc.contributor.authorChen, Wei-Ting
dc.contributor.authorCohen-Salmon, Martine
dc.contributor.authorCunningham, Colm
dc.contributor.authorDeneen, Benjamin
dc.contributor.authorDe Strooper, Bart
dc.contributor.authorDíaz-Castro, Blanca
dc.contributor.authorFarina, Cinthia
dc.contributor.authorFreeman, Marc
dc.contributor.authorGallo, Vittorio
dc.contributor.authorGoldman, James E
dc.contributor.authorGoldman, Steven A
dc.contributor.authorGötz, Magdalena
dc.contributor.authorGutiérrez, Antonia
dc.contributor.authorHaydon, Philip G
dc.contributor.authorHeiland, Dieter H
dc.contributor.authorHol, Elly M
dc.contributor.authorHolt, Matthew G
dc.contributor.authorIino, Masamitsu
dc.contributor.authorKastanenka, Ksenia V
dc.contributor.authorKettenmann, Helmut
dc.contributor.authorKhakh, Baljit S
dc.contributor.authorKoizumi, Schuichi
dc.contributor.authorLee, C Justin
dc.contributor.authorLiddelow, Shane A
dc.contributor.authorMacVicar, Brian A
dc.contributor.authorMagistretti, Pierre J.
dc.contributor.authorMessing, Albee
dc.contributor.authorMishra, Anusha
dc.contributor.authorMolofsky, Anna V
dc.contributor.authorMurai, Keith K
dc.contributor.authorNorris, Christopher M
dc.contributor.authorOkada, Seiji
dc.contributor.authorOliet, Stéphane H R
dc.contributor.authorOliveira, João F
dc.contributor.authorPanatier, Aude
dc.contributor.authorParpura, Vladimir
dc.contributor.authorPekna, Marcela
dc.contributor.authorPekny, Milos
dc.contributor.authorPellerin, Luc
dc.contributor.authorPerea, Gertrudis
dc.contributor.authorPérez-Nievas, Beatriz G
dc.contributor.authorPfrieger, Frank W
dc.contributor.authorPoskanzer, Kira E
dc.contributor.authorQuintana, Francisco J
dc.contributor.authorRansohoff, Richard M
dc.contributor.authorRiquelme-Perez, Miriam
dc.contributor.authorRobel, Stefanie
dc.contributor.authorRose, Christine R
dc.contributor.authorRothstein, Jeffrey D
dc.contributor.authorRouach, Nathalie
dc.contributor.authorRowitch, David H
dc.contributor.authorSemyanov, Alexey
dc.contributor.authorSirko, Swetlana
dc.contributor.authorSontheimer, Harald
dc.contributor.authorSwanson, Raymond A
dc.contributor.authorVitorica, Javier
dc.contributor.authorWanner, Ina-Beate
dc.contributor.authorWood, Levi B
dc.contributor.authorWu, Jiaqian
dc.contributor.authorZheng, Binhai
dc.contributor.authorZimmer, Eduardo R
dc.contributor.authorZorec, Robert
dc.contributor.authorSofroniew, Michael V
dc.contributor.authorVerkhratsky, Alexei
dc.date.accessioned2021-02-21T12:24:43Z
dc.date.available2021-02-21T12:24:43Z
dc.date.issued2021-02-16
dc.identifier.citationEscartin, C., Galea, E., Lakatos, A., O’Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., … Agarwal, A. (2021). Reactive astrocyte nomenclature, definitions, and future directions. Nature Neuroscience. doi:10.1038/s41593-020-00783-4
dc.identifier.issn1097-6256
dc.identifier.pmid33589835
dc.identifier.doi10.1038/s41593-020-00783-4
dc.identifier.urihttp://hdl.handle.net/10754/667528
dc.description.abstractReactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is also unclear whether fixed categories of reactive astrocytes exist and, if so, how to identify them. We point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. We advocate, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters-preferably in vivo-plus multivariate statistics and determination of impact on pathological hallmarks in relevant models. These guidelines may spur the discovery of astrocyte-based biomarkers as well as astrocyte-targeting therapies that abrogate detrimental actions of reactive astrocytes, potentiate their neuro- and glioprotective actions, and restore or augment their homeostatic, modulatory, and defensive functions.
dc.description.sponsorshipCNRS, CEA, ANR, and France Alzheimer to CE.; MCINN (PID2019-107633RB-I00) and Generalitat de Catalunya (2017-SGR547, Grup de demències Sant Pau) to E.G. US Centers for Disease Control and Prevention to J. P.O. Alzheimer’s Association (AACF-17-524184) and NIH-NIA (K08AG064039) to A.S.-P. DFG (SPP1757, STE 552/5, STE 552/4), EU (H2020-MSCA-ITN project 722053 EU-GliaPhD) and BMBF (16GW0182 CONNEXIN) to C.S. Swiss National Science Foundation grant 31003A 173124/1; SNSF NCCR ‘Transcure’ (51NF40-160620); Synapsis Foundation Heidi Seiler-Stiftung 2018-PI01 to A.Volterra. NIH-NINDS (NS084030), Dr. Miriam and Sheldon G. Adelson Medical Foundation and Wings for Life to M.V.S. The authors thank T. Yohannan of Alpha Language Services, Barcelona, for expert copy editing.
dc.publisherSpringer Nature
dc.relation.urlhttp://www.nature.com/articles/s41593-020-00783-4
dc.rightsArchived with thanks to Nature neuroscience
dc.titleReactive astrocyte nomenclature, definitions, and future directions.
dc.typeArticle
dc.contributor.departmentBioscience Program
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentOffice of the President
dc.identifier.journalNature neuroscience
dc.rights.embargodate2021-08-16
dc.eprint.versionPost-print
dc.contributor.institutionCentre de Neurosciences Psychiatriques, University of Lausanne and CHUV, Site de Cery, Prilly-Lausanne, Lausanne, Switzerland.
kaust.personMagistretti, Pierre J.


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