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    Reactive astrocyte nomenclature, definitions, and future directions.

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    Type
    Article
    Authors
    Escartin, Carole
    Galea, Elena
    Lakatos, András
    O'Callaghan, James P
    Petzold, Gabor C
    Serrano-Pozo, Alberto
    Steinhäuser, Christian
    Volterra, Andrea
    Carmignoto, Giorgio
    Agarwal, Amit
    Allen, Nicola J
    Araque, Alfonso
    Barbeito, Luis
    Barzilai, Ari
    Bergles, Dwight E
    Bonvento, Gilles
    Butt, Arthur M
    Chen, Wei-Ting
    Cohen-Salmon, Martine
    Cunningham, Colm
    Deneen, Benjamin
    De Strooper, Bart
    Díaz-Castro, Blanca
    Farina, Cinthia
    Freeman, Marc
    Gallo, Vittorio
    Goldman, James E
    Goldman, Steven A
    Götz, Magdalena
    Gutiérrez, Antonia
    Haydon, Philip G
    Heiland, Dieter H
    Hol, Elly M
    Holt, Matthew G
    Iino, Masamitsu
    Kastanenka, Ksenia V
    Kettenmann, Helmut
    Khakh, Baljit S
    Koizumi, Schuichi
    Lee, C Justin
    Liddelow, Shane A
    MacVicar, Brian A
    Magistretti, Pierre J. cc
    Messing, Albee
    Mishra, Anusha
    Molofsky, Anna V
    Murai, Keith K
    Norris, Christopher M
    Okada, Seiji
    Oliet, Stéphane H R
    Oliveira, João F
    Panatier, Aude
    Parpura, Vladimir
    Pekna, Marcela
    Pekny, Milos
    Pellerin, Luc
    Perea, Gertrudis
    Pérez-Nievas, Beatriz G
    Pfrieger, Frank W
    Poskanzer, Kira E
    Quintana, Francisco J
    Ransohoff, Richard M
    Riquelme-Perez, Miriam
    Robel, Stefanie
    Rose, Christine R
    Rothstein, Jeffrey D
    Rouach, Nathalie
    Rowitch, David H
    Semyanov, Alexey
    Sirko, Swetlana
    Sontheimer, Harald
    Swanson, Raymond A
    Vitorica, Javier
    Wanner, Ina-Beate
    Wood, Levi B
    Wu, Jiaqian
    Zheng, Binhai
    Zimmer, Eduardo R
    Zorec, Robert
    Sofroniew, Michael V
    Verkhratsky, Alexei
    KAUST Department
    Bioscience Program
    Biological and Environmental Sciences and Engineering (BESE) Division
    Office of the President
    Date
    2021-02-16
    Embargo End Date
    2021-08-16
    Permanent link to this record
    http://hdl.handle.net/10754/667528
    
    Metadata
    Show full item record
    Abstract
    Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is also unclear whether fixed categories of reactive astrocytes exist and, if so, how to identify them. We point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. We advocate, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters-preferably in vivo-plus multivariate statistics and determination of impact on pathological hallmarks in relevant models. These guidelines may spur the discovery of astrocyte-based biomarkers as well as astrocyte-targeting therapies that abrogate detrimental actions of reactive astrocytes, potentiate their neuro- and glioprotective actions, and restore or augment their homeostatic, modulatory, and defensive functions.
    Citation
    Escartin, C., Galea, E., Lakatos, A., O’Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., … Agarwal, A. (2021). Reactive astrocyte nomenclature, definitions, and future directions. Nature Neuroscience. doi:10.1038/s41593-020-00783-4
    Sponsors
    CNRS, CEA, ANR, and France Alzheimer to CE.; MCINN (PID2019-107633RB-I00) and Generalitat de Catalunya (2017-SGR547, Grup de demències Sant Pau) to E.G. US Centers for Disease Control and Prevention to J. P.O. Alzheimer’s Association (AACF-17-524184) and NIH-NIA (K08AG064039) to A.S.-P. DFG (SPP1757, STE 552/5, STE 552/4), EU (H2020-MSCA-ITN project 722053 EU-GliaPhD) and BMBF (16GW0182 CONNEXIN) to C.S. Swiss National Science Foundation grant 31003A 173124/1; SNSF NCCR ‘Transcure’ (51NF40-160620); Synapsis Foundation Heidi Seiler-Stiftung 2018-PI01 to A.Volterra. NIH-NINDS (NS084030), Dr. Miriam and Sheldon G. Adelson Medical Foundation and Wings for Life to M.V.S. The authors thank T. Yohannan of Alpha Language Services, Barcelona, for expert copy editing.
    Publisher
    Springer Science and Business Media LLC
    Journal
    Nature neuroscience
    DOI
    10.1038/s41593-020-00783-4
    PubMed ID
    33589835
    Additional Links
    http://www.nature.com/articles/s41593-020-00783-4
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41593-020-00783-4
    Scopus Count
    Collections
    Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program

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