Reactive astrocyte nomenclature, definitions, and future directions.
Type
ArticleAuthors
Escartin, CaroleGalea, Elena
Lakatos, András
O'Callaghan, James P
Petzold, Gabor C
Serrano-Pozo, Alberto
Steinhäuser, Christian
Volterra, Andrea
Carmignoto, Giorgio
Agarwal, Amit
Allen, Nicola J
Araque, Alfonso
Barbeito, Luis
Barzilai, Ari
Bergles, Dwight E
Bonvento, Gilles
Butt, Arthur M
Chen, Wei-Ting
Cohen-Salmon, Martine
Cunningham, Colm
Deneen, Benjamin
De Strooper, Bart
Díaz-Castro, Blanca
Farina, Cinthia
Freeman, Marc
Gallo, Vittorio
Goldman, James E
Goldman, Steven A
Götz, Magdalena
Gutiérrez, Antonia
Haydon, Philip G
Heiland, Dieter H
Hol, Elly M
Holt, Matthew G
Iino, Masamitsu
Kastanenka, Ksenia V
Kettenmann, Helmut
Khakh, Baljit S
Koizumi, Schuichi
Lee, C Justin
Liddelow, Shane A
MacVicar, Brian A
Magistretti, Pierre J.

Messing, Albee
Mishra, Anusha
Molofsky, Anna V
Murai, Keith K
Norris, Christopher M
Okada, Seiji
Oliet, Stéphane H R
Oliveira, João F
Panatier, Aude
Parpura, Vladimir
Pekna, Marcela
Pekny, Milos
Pellerin, Luc
Perea, Gertrudis
Pérez-Nievas, Beatriz G
Pfrieger, Frank W
Poskanzer, Kira E
Quintana, Francisco J
Ransohoff, Richard M
Riquelme-Perez, Miriam
Robel, Stefanie
Rose, Christine R
Rothstein, Jeffrey D
Rouach, Nathalie
Rowitch, David H
Semyanov, Alexey
Sirko, Swetlana
Sontheimer, Harald
Swanson, Raymond A
Vitorica, Javier
Wanner, Ina-Beate
Wood, Levi B
Wu, Jiaqian
Zheng, Binhai
Zimmer, Eduardo R
Zorec, Robert
Sofroniew, Michael V
Verkhratsky, Alexei
KAUST Department
Bioscience ProgramBiological and Environmental Sciences and Engineering (BESE) Division
Office of the President
Date
2021-02-16Embargo End Date
2021-08-16Permanent link to this record
http://hdl.handle.net/10754/667528
Metadata
Show full item recordAbstract
Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is also unclear whether fixed categories of reactive astrocytes exist and, if so, how to identify them. We point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. We advocate, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters-preferably in vivo-plus multivariate statistics and determination of impact on pathological hallmarks in relevant models. These guidelines may spur the discovery of astrocyte-based biomarkers as well as astrocyte-targeting therapies that abrogate detrimental actions of reactive astrocytes, potentiate their neuro- and glioprotective actions, and restore or augment their homeostatic, modulatory, and defensive functions.Citation
Escartin, C., Galea, E., Lakatos, A., O’Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., … Agarwal, A. (2021). Reactive astrocyte nomenclature, definitions, and future directions. Nature Neuroscience. doi:10.1038/s41593-020-00783-4Sponsors
CNRS, CEA, ANR, and France Alzheimer to CE.; MCINN (PID2019-107633RB-I00) and Generalitat de Catalunya (2017-SGR547, Grup de demències Sant Pau) to E.G. US Centers for Disease Control and Prevention to J. P.O. Alzheimer’s Association (AACF-17-524184) and NIH-NIA (K08AG064039) to A.S.-P. DFG (SPP1757, STE 552/5, STE 552/4), EU (H2020-MSCA-ITN project 722053 EU-GliaPhD) and BMBF (16GW0182 CONNEXIN) to C.S. Swiss National Science Foundation grant 31003A 173124/1; SNSF NCCR ‘Transcure’ (51NF40-160620); Synapsis Foundation Heidi Seiler-Stiftung 2018-PI01 to A.Volterra. NIH-NINDS (NS084030), Dr. Miriam and Sheldon G. Adelson Medical Foundation and Wings for Life to M.V.S. The authors thank T. Yohannan of Alpha Language Services, Barcelona, for expert copy editing.Publisher
Springer Science and Business Media LLCJournal
Nature neurosciencePubMed ID
33589835Additional Links
http://www.nature.com/articles/s41593-020-00783-4ae974a485f413a2113503eed53cd6c53
10.1038/s41593-020-00783-4
Scopus Count
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