Interaction between transforming Theileria parasites and their host bovine leukocytes
KAUST DepartmentBiological and Environmental Science and Engineering (BESE) Division
KAUST Grant NumberOSR-2015-CRG4-2610
Embargo End Date2022-02-09
Permanent link to this recordhttp://hdl.handle.net/10754/667403
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AbstractTheileria are tick-transmitted parasites that cause often fatal leuko-proliferative diseases in cattle called tropical theileriosis (T. annulata) and East Coast fever (T. parva). However, upon treatment with anti-theilerial drug-transformed leukocytes die of apoptosis indicating that Theileria-induced transformation is reversible making infected leukocytes a powerful example of how intracellular parasites interact with their hosts. Theileria-transformed leukocytes disseminate throughout infected cattle causing a cancer-like disease and here, we discuss how cytokines, noncoding RNAs and oncometabolites can contribute to the transformed phenotype and disease pathology.
CitationTajeri, S., Haidar, M., Sakura, T., & Langsley, G. (2021). Interaction between transforming Theileria parasites and their host bovine leukocytes. Molecular Microbiology. doi:10.1111/mmi.14642
SponsorsST and TS acknowledge postdoctoral fellowships from ParaFrap (ANR-11-LABX-0024) and MH postdoctoral funding from a Competitive Research Grant from the Office for Sponsored Research (OSR-2015-CRG4-2610) at King Abdullah University of Science and Technology (KAUST) awarded to Arnab Pain and GL. The RNAseq data in Figure 2 were generated by MH, while a post-doc in Arnab Pain’s laboratory. GL also acknowledges ANR-11-LABX-0024 and core support from INSERM and the CNRS.
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