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    Implantable Nanosensors for Human Steroid Hormone Sensing In Vivo Using a Self-Templating Corona Phase Molecular Recognition

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    Type
    Article
    Authors
    Lee, Michael A.
    Wang, Song
    Jin, Xiaojia
    Bakh, Naveed Ali
    Nguyen, Freddy T.
    Dong, Juyao
    Silmore, Kevin S. cc
    Gong, Xun
    Pham, Crystal
    Jones, Kelvin K.
    Muthupalani, Sureshkumar
    Bisker, Gili
    Son, Manki
    Strano, Michael S cc
    KAUST Grant Number
    OSR-2015 Sensors 2707
    Date
    2020-09-16
    Embargo End Date
    2021-09-16
    Permanent link to this record
    http://hdl.handle.net/10754/667362
    
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    Abstract
    Dynamic measurements of steroid hormones in vivo are critical, but steroid sensing is currently limited by the availability of specific molecular recognition elements due to the chemical similarity of these hormones. In this work, a new, self-templating synthetic approach is applied using corona phase molecular recognition (CoPhMoRe) targeting the steroid family of molecules to produce near infrared fluorescent, implantable sensors. A key limitation of CoPhMoRe has been its reliance on library generation for sensor screening. This problem is addressed with a self-templating strategy of polymer design, using the examples of progesterone and cortisol sensing based on a styrene and acrylic acid copolymer library augmented with an acrylated steroid. The pendant steroid attached to the corona backbone is shown to self-template the phase, providing a unique CoPhMoRE design strategy with high efficacy. The resulting sensors exhibit excellent stability and reversibility upon repeated analyte cycling. It is shown that molecular recognition using such constructs is viable even in vivo after sensor implantation into a murine model by employing a poly (ethylene glycol) diacrylate (PEGDA) hydrogel and porous cellulose interface to limit nonspecific absorption. The results demonstrate that CoPhMoRe templating is sufficiently robust to enable a new class of continuous, in vivo biosensors.
    Citation
    Lee, M. A., Wang, S., Jin, X., Bakh, N. A., Nguyen, F. T., Dong, J., … Strano, M. S. (2020). Implantable Nanosensors for Human Steroid Hormone Sensing In Vivo Using a Self-Templating Corona Phase Molecular Recognition. Advanced Healthcare Materials, 9(21), 2000429. doi:10.1002/adhm.202000429
    Sponsors
    This research was supported by the King Abdullah University of Science & Technology (OSR-2015 Sensors 2707) and Juvenile Diabetes Research Foundation United States of America (3-SRA-2017-426-A-N). The research was partially supported by an award from the Walmart Foundation and the Walmart Food Safety Collaboration Center in Beijing. F.T.N. is supported by the Arnold and Mabel Beckman Foundation through the Arnold O. Beckman Postdoctoral Fellowship. G.B. acknowledges the support of the Zuckerman STEM Leadership Program, the Israel Science Foundation (grant No. 456/18), and the Nicholas and Elizabeth Slezak Super Center for Cardiac Research and Biomedical Engineering at Tel Aviv University. K.S.S was supported by the Department of Energy Computational Science Graduate Fellowship program under grant DE-FG02-97ER25308.
    Publisher
    Wiley
    Journal
    Advanced Healthcare Materials
    DOI
    10.1002/adhm.202000429
    Additional Links
    https://onlinelibrary.wiley.com/doi/10.1002/adhm.202000429
    ae974a485f413a2113503eed53cd6c53
    10.1002/adhm.202000429
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