Show simple item record

dc.contributor.authorBabatain, Wedyan
dc.contributor.authorGumus, Abdurrahman
dc.contributor.authorWicaksono, Irmandy
dc.contributor.authorButtner, Ulrich
dc.contributor.authorElatab, Nazek
dc.contributor.authorRehman, Mutee Ur
dc.contributor.authorQaiser, Nadeem
dc.contributor.authorConchouso Gonzalez, David
dc.contributor.authorHussain, Muhammad Mustafa
dc.date.accessioned2021-02-08T06:55:31Z
dc.date.available2021-02-08T06:55:31Z
dc.date.issued2020-09-09
dc.date.submitted2020-04-29
dc.identifier.citationBabatain, W., Gumus, A., Wicaksono, I., Buttner, U., El-atab, N., Rehman, M. U., … Hussain, M. M. (2020). Expandable Polymer Assisted Wearable Personalized Medicinal Platform. Advanced Materials Technologies, 5(10), 2000411. doi:10.1002/admt.202000411
dc.identifier.issn2365-709X
dc.identifier.doi10.1002/admt.202000411
dc.identifier.doi10.1002/admt.202070064
dc.identifier.urihttp://hdl.handle.net/10754/667280
dc.description.abstractConventional healthcare, thoughts of treatment, and practice of medicine largely rely on the traditional concept of one size fits all. Personalized medicine is an emerging therapeutic approach that aims to develop a therapeutic technique that provides tailor-made therapy based on everyone’s individual needs by delivering the right drug at the right time with the right amount of dosage. Advancement in technologies such as wearable biosensors, point-of-care diagnostics, microfluidics, and artificial intelligence can enable the realization of effective personalized therapy. However, currently, there is a lack of a personalized minimally invasive wearable closed-loop drug delivery system that is continuous, automated, conformal to the skin, and cost-effective. Here, design, fabrication, optimization, and application of a personalized medicinal platform augmented with flexible biosensors, heaters, expandable actuator and processing units powered by a lightweight battery are shown. The platform provides precise drug delivery and preparation with spatiotemporal control over the administered dose as a response to real-time physiological changes of the individual. The system is conformal to the skin, and the drug is transdermally administered through an integrated microneedle. The developed platform is fabricated using rapid, cost-effective techniques that are independent of advanced microfabrication facilities to expand its applications to low-resource environments.
dc.description.sponsorshipThis publication was based upon work supported by the King Abdullah University of Science and Technology (KAUST) Office of Sponsored Research (OSR) under Award No. REP/1/2880-01-01.
dc.publisherWiley
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/10.1002/admt.202000411
dc.rightsArchived with thanks to Advanced Materials Technologies
dc.titleExpandable Polymer Assisted Wearable Personalized Medicinal Platform
dc.typeArticle
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentElectrical Engineering
dc.contributor.departmentElectrical Engineering Program
dc.contributor.departmentIntegrated Nanotechnology Lab
dc.contributor.departmentMicrofluidics
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.identifier.journalAdvanced Materials Technologies
dc.rights.embargodate2021-09-09
dc.eprint.versionPost-print
dc.contributor.institutionDepartment of Electrical and Electronics Engineering, Izmir Institute of Technology, Urla, Izmir, 35430, Turkey
dc.contributor.institutionMIT Media Lab, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
dc.contributor.institutionEECS, Cory Hall, University of California Berkeley, Berkeley, CA, 94720, USA
dc.identifier.volume5
dc.identifier.issue10
dc.identifier.pages2000411
kaust.personBabatain, Wedyan
kaust.personBabatain, Wedyan
kaust.personGumus, Abdurrahman
kaust.personWicaksono, Irmandy
kaust.personButtner, Ulrich
kaust.personButtner, Ulrich
kaust.personElatab, Nazek
kaust.personElatab, Nazek
kaust.personRehman, Mutee Ur
kaust.personQaiser, Nadeem
kaust.personQaiser, Nadeem
kaust.personConchouso Gonzalez, David
kaust.personConchouso Gonzalez, David
kaust.personHussain, Muhammad Mustafa
kaust.personHussain, Muhammad Mustafa
kaust.grant.numberREP/1/2880-01-01
dc.date.accepted2020-06-16
dc.identifier.eid2-s2.0-85090467815
refterms.dateFOA2021-02-08T10:16:54Z
kaust.acknowledged.supportUnitOffice of Sponsored Research (OSR)


Files in this item

Thumbnail
Name:
Main Article_revision_Wedyan.pdf
Size:
2.487Mb
Format:
PDF
Description:
Accepted manuscript

This item appears in the following Collection(s)

Show simple item record