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    Expandable Polymer Assisted Wearable Personalized Medicinal Platform

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    Name:
    Main Article_revision_Wedyan.pdf
    Size:
    2.487Mb
    Format:
    PDF
    Description:
    Accepted manuscript
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    Type
    Article
    Authors
    Babatain, Wedyan cc
    Gumus, Abdurrahman
    Wicaksono, Irmandy
    Buttner, Ulrich
    Elatab, Nazek cc
    Rehman, Mutee Ur
    Qaiser, Nadeem cc
    Conchouso Gonzalez, David cc
    Hussain, Muhammad Mustafa cc
    KAUST Department
    Computational Bioscience Research Center (CBRC)
    Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division
    Electrical and Computer Engineering
    Electrical and Computer Engineering Program
    Integrated Nanotechnology Lab
    Microfluidics
    Physical Science and Engineering (PSE) Division
    KAUST Grant Number
    REP/1/2880-01-01
    Date
    2020-09-09
    Embargo End Date
    2021-09-09
    Submitted Date
    2020-04-29
    Permanent link to this record
    http://hdl.handle.net/10754/667280
    
    Metadata
    Show full item record
    Abstract
    Conventional healthcare, thoughts of treatment, and practice of medicine largely rely on the traditional concept of one size fits all. Personalized medicine is an emerging therapeutic approach that aims to develop a therapeutic technique that provides tailor-made therapy based on everyone’s individual needs by delivering the right drug at the right time with the right amount of dosage. Advancement in technologies such as wearable biosensors, point-of-care diagnostics, microfluidics, and artificial intelligence can enable the realization of effective personalized therapy. However, currently, there is a lack of a personalized minimally invasive wearable closed-loop drug delivery system that is continuous, automated, conformal to the skin, and cost-effective. Here, design, fabrication, optimization, and application of a personalized medicinal platform augmented with flexible biosensors, heaters, expandable actuator and processing units powered by a lightweight battery are shown. The platform provides precise drug delivery and preparation with spatiotemporal control over the administered dose as a response to real-time physiological changes of the individual. The system is conformal to the skin, and the drug is transdermally administered through an integrated microneedle. The developed platform is fabricated using rapid, cost-effective techniques that are independent of advanced microfabrication facilities to expand its applications to low-resource environments.
    Citation
    Babatain, W., Gumus, A., Wicaksono, I., Buttner, U., El-atab, N., Rehman, M. U., … Hussain, M. M. (2020). Expandable Polymer Assisted Wearable Personalized Medicinal Platform. Advanced Materials Technologies, 5(10), 2000411. doi:10.1002/admt.202000411
    Sponsors
    This publication was based upon work supported by the King Abdullah University of Science and Technology (KAUST) Office of Sponsored Research (OSR) under Award No. REP/1/2880-01-01.
    Publisher
    Wiley
    Journal
    Advanced Materials Technologies
    DOI
    10.1002/admt.202000411
    10.1002/admt.202070064
    Additional Links
    https://onlinelibrary.wiley.com/doi/10.1002/admt.202000411
    ae974a485f413a2113503eed53cd6c53
    10.1002/admt.202000411
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division; Electrical and Computer Engineering Program; Integrated Nanotechnology Lab; Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division

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