Show simple item record

dc.contributor.authorPolishchuk, Iuliia
dc.contributor.authorSklyaruk, Jan
dc.contributor.authorLebedev, Yury
dc.contributor.authorRueping, Magnus
dc.date.accessioned2021-01-31T08:17:11Z
dc.date.available2021-01-31T08:17:11Z
dc.date.issued2021-01-28
dc.date.submitted2020-12-29
dc.identifier.citationPolishchuk, I., Sklyaruk, J., Lebedev, Y., & Rueping, M. (2021). Air Stable Iridium Catalysts for Direct Reductive Amination of Ketones. Chemistry – A European Journal. doi:10.1002/chem.202005508
dc.identifier.issn0947-6539
dc.identifier.pmid33508154
dc.identifier.doi10.1002/chem.202005508
dc.identifier.urihttp://hdl.handle.net/10754/667114
dc.description.abstractHalf-sandwich iridium complexes bearing bidentate urea-phosphorus ligands were found to catalyze the direct reductive amination of aromatic and aliphatic ketones under mild conditions at 0.5 mol.% loading with high selectivity towards primary amines. One of the complexes was found to be active in both the Leuckart-Wallach (NH4CO2H) type reaction as well as in the hydrogenative (H2/NH4AcO) reductive amination. The protocol with ammonium formate does not require an inert atmosphere, dry solvents, as well as additives and in contrast to previous reports takes place in HFIP instead of methanol. Applying NH4CO2D or D2 resulted in a high degree of deuterium incorporation into the primary amine α-position.
dc.publisherWiley
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/10.1002/chem.202005508
dc.rightsArchived with thanks to Chemistry (Weinheim an der Bergstrasse, Germany)
dc.titleAir Stable Iridium Catalysts for Direct Reductive Amination of Ketones.
dc.typeArticle
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.contributor.departmentChemical Science Program
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.identifier.journalChemistry (Weinheim an der Bergstrasse, Germany)
dc.rights.embargodate2022-01-28
dc.eprint.versionPost-print
dc.contributor.institutionRWTH: Rheinisch-Westfalische Technische Hochschule Aachen Organic Chemistry GERMANY
dc.contributor.institutionRWTH: Rheinisch-Westfalische Technische Hochschule Aachen Department of Chemistry GERMANY
kaust.personLebedev, Yury
kaust.personRueping, Magnus
dc.date.accepted2021-01-27
refterms.dateFOA2021-01-31T08:18:07Z


Files in this item

Thumbnail
Name:
air stable_chem.202005508.pdf
Size:
953.1Kb
Format:
PDF
Description:
Accepted manuscript
Embargo End Date:
2022-01-28

This item appears in the following Collection(s)

Show simple item record