Air Stable Iridium Catalysts for Direct Reductive Amination of Ketones.
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2022-01-28
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ArticleKAUST Department
KAUST Catalysis Center (KCC)Chemical Science Program
Physical Science and Engineering (PSE) Division
Biological and Environmental Sciences and Engineering (BESE) Division
Date
2021-01-28Embargo End Date
2022-01-28Submitted Date
2020-12-29Permanent link to this record
http://hdl.handle.net/10754/667114
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Half-sandwich iridium complexes bearing bidentate urea-phosphorus ligands were found to catalyze the direct reductive amination of aromatic and aliphatic ketones under mild conditions at 0.5 mol.% loading with high selectivity towards primary amines. One of the complexes was found to be active in both the Leuckart-Wallach (NH4CO2H) type reaction as well as in the hydrogenative (H2/NH4AcO) reductive amination. The protocol with ammonium formate does not require an inert atmosphere, dry solvents, as well as additives and in contrast to previous reports takes place in HFIP instead of methanol. Applying NH4CO2D or D2 resulted in a high degree of deuterium incorporation into the primary amine α-position.Citation
Polishchuk, I., Sklyaruk, J., Lebedev, Y., & Rueping, M. (2021). Air Stable Iridium Catalysts for Direct Reductive Amination of Ketones. Chemistry – A European Journal. doi:10.1002/chem.202005508Publisher
WileyPubMed ID
33508154Additional Links
https://onlinelibrary.wiley.com/doi/10.1002/chem.202005508ae974a485f413a2113503eed53cd6c53
10.1002/chem.202005508
Scopus Count
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