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    Ultrashort Peptide Bioinks Support Automated Printing of Large-Scale Constructs Assuring Long-Term Survival of Printed Tissue Constructs

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    manuscript Hauser.pdf
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    Description:
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    Type
    Article
    Authors
    Susapto, Hepi Hari cc
    Alhattab, Dana Majed cc
    Abdelrahman, Sherin cc
    Khan, Zainab
    Alshehri, Salwa
    Kahin, Kowther
    Ge, Rui
    Moretti, Manola cc
    Emwas, Abdul-Hamid M.
    Hauser, Charlotte cc
    KAUST Department
    Biological and Environmental Science and Engineering (BESE) Division
    Bioscience Program
    Computational Bioscience Research Center (CBRC)
    Laboratory for Nanomedicine
    NMR
    Physical Science and Engineering (PSE) Division
    Date
    2021-01-25
    Online Publication Date
    2021-01-25
    Print Publication Date
    2021-04-14
    Embargo End Date
    2022-01-25
    Submitted Date
    2020-11-07
    Permanent link to this record
    http://hdl.handle.net/10754/667000
    
    Metadata
    Show full item record
    Abstract
    We report about rationally designed ultrashort peptide bioinks, overcoming severe limitations in current bioprinting procedures. Bioprinting is increasingly relevant in tissue engineering, regenerative and personalized medicine due to its ability to fabricate complex tissue scaffolds through an automated deposition process. Printing stable large-scale constructs with high shape fidelity and enabling long-term cell survival are major challenges that most existing bioinks are unable to solve. Additionally, they require chemical or UV-cross-linking for the structure-solidifying process which compromises the encapsulated cells, resulting in restricted structure complexity and low cell viability. Using ultrashort peptide bioinks as ideal bodylike but synthetic material, we demonstrate an instant solidifying cell-embedding printing process via a sophisticated extrusion procedure under true physiological conditions and at cost-effective low bioink concentrations. Our printed large-scale cell constructs and the chondrogenic differentiation of printed mesenchymal stem cells point to the strong potential of the peptide bioinks for automated complex tissue fabrication.
    Citation
    Susapto, H. H., Alhattab, D., Abdelrahman, S., Khan, Z., Alshehri, S., Kahin, K., … Hauser, C. A. E. (2021). Ultrashort Peptide Bioinks Support Automated Printing of Large-Scale Constructs Assuring Long-Term Survival of Printed Tissue Constructs. Nano Letters. doi:10.1021/acs.nanolett.0c04426
    Sponsors
    This work was financially supported by King Abdullah University of Science and Technology. The authors acknowledge KAUST’s Seed Fund Grant and KAUST’s Innovation Fund awarded by KAUST’s Innovation and Economic Development.
    The authors acknowledge Jordy Homing Lam for advising on the MD simulations and Ali H. Aldoukhi for 3D bioprinting support. We acknowledge the strong support from Rachid Sougrat, Ali R. Behzad, and Lingyun Zhao, KAUST Core Laboratories. We also acknowledge Walaa Alsanie, Raed Felimban, and Adeel Chaudhary for providing the mouse embryonic neuronal cells.
    Publisher
    American Chemical Society (ACS)
    Journal
    Nano Letters
    DOI
    10.1021/acs.nanolett.0c04426
    ae974a485f413a2113503eed53cd6c53
    10.1021/acs.nanolett.0c04426
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; Physical Science and Engineering (PSE) Division; Computational Bioscience Research Center (CBRC)

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