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dc.contributor.authorNelson, David R
dc.contributor.authorHazzouri, Khaled M
dc.contributor.authorLauersen, Kyle J
dc.contributor.authorJaiswal, Ashish
dc.contributor.authorChaiboonchoe, Amphun
dc.contributor.authorMystikou, Alexandra
dc.contributor.authorFu, Weiqi
dc.contributor.authorDaakour, Sarah
dc.contributor.authorDohai, Bushra
dc.contributor.authorAlzahmi, Amnah
dc.contributor.authorNobles, David
dc.contributor.authorHurd, Mark
dc.contributor.authorSexton, Julie
dc.contributor.authorPreston, Michael J
dc.contributor.authorBlanchette, Joan
dc.contributor.authorLomas, Michael W
dc.contributor.authorAmiri, Khaled M A
dc.contributor.authorSalehi-Ashtiani, Kourosh
dc.date.accessioned2021-01-20T11:36:46Z
dc.date.available2021-01-20T11:36:46Z
dc.date.issued2021-01-12
dc.date.submitted2020-06-22
dc.identifier.citationNelson, D. R., Hazzouri, K. M., Lauersen, K. J., Jaiswal, A., Chaiboonchoe, A., Mystikou, A., … Salehi-Ashtiani, K. (2021). Large-scale genome sequencing reveals the driving forces of viruses in microalgal evolution. Cell Host & Microbe. doi:10.1016/j.chom.2020.12.005
dc.identifier.issn1931-3128
dc.identifier.pmid33434515
dc.identifier.doi10.1016/j.chom.2020.12.005
dc.identifier.urihttp://hdl.handle.net/10754/666949
dc.description.abstractBeing integral primary producers in diverse ecosystems, microalgal genomes could be mined for ecological insights, but representative genome sequences are lacking for many phyla. We cultured and sequenced 107 microalgae species from 11 different phyla indigenous to varied geographies and climates. This collection was used to resolve genomic differences between saltwater and freshwater microalgae. Freshwater species showed domain-centric ontology enrichment for nuclear and nuclear membrane functions, while saltwater species were enriched in organellar and cellular membrane functions. Further, marine species contained significantly more viral families in their genomes (p = 8e-4). Sequences from Chlorovirus, Coccolithovirus, Pandoravirus, Marseillevirus, Tupanvirus, and other viruses were found integrated into the genomes of algal from marine environments. These viral-origin sequences were found to be expressed and code for a wide variety of functions. Together, this study comprehensively defines the expanse of protein-coding and viral elements in microalgal genomes and posits a unified adaptive strategy for algal halotolerance.
dc.description.sponsorshipWe thank the NYUAD High-Performance Computing Center for providing computational resources. This work was supported by Tamkeen under the NYU Abu Dhabi Research Institute grant to the NYUAD Center for Genomics and Systems Biology (73 71210 CGSB9), and by NYUAD Faculty Research Funds (AD060).
dc.publisherElsevier BV
dc.relation.urlhttps://linkinghub.elsevier.com/retrieve/pii/S1931312820306673
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Cell host & microbe. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Cell host & microbe, [, , (2021-01-12)] DOI: 10.1016/j.chom.2020.12.005 . © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleLarge-scale genome sequencing reveals the driving forces of viruses in microalgal evolution.
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.
dc.identifier.journalCell host & microbe
dc.rights.embargodate2022-01-12
dc.eprint.versionPost-print
dc.contributor.institutionCenter for Genomics and Systems Biology, New York University Abu Dhabi, Abu Dhabi, UAE.
dc.contributor.institutionKhalifa Center for Genetic Engineering and Biotechnology (KCGEB), UAE University, Al Ain, Abu Dhabi, UAE.
dc.contributor.institutionBiology Department, College of Science, UAE University, Al Ain, Abu Dhabi, UAE.
dc.contributor.institutionDivision of Science and Math, New York University Abu Dhabi, Abu Dhabi, UAE.
dc.contributor.institutionUTEX Culture Collection of Algae at the University of Texas at Austin, Austin, TX, USA.
dc.contributor.institutionNational Center for Marine Algae and Microbiota, East Boothbay, ME, USA.
kaust.personLauersen, Kyle J
dc.date.accepted2020-11-18


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