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dc.contributor.authorTauffenberger, Arnaud
dc.contributor.authorMagistretti, Pierre J.
dc.date.accessioned2021-01-19T10:59:05Z
dc.date.available2021-01-19T10:59:05Z
dc.date.issued2021-01-13
dc.date.submitted2020-04-22
dc.identifier.citationTauffenberger, A., & Magistretti, P. J. (2021). Reactive Oxygen Species: Beyond Their Reactive Behavior. Neurochemical Research. doi:10.1007/s11064-020-03208-7
dc.identifier.issn0364-3190
dc.identifier.pmid33439432
dc.identifier.doi10.1007/s11064-020-03208-7
dc.identifier.urihttp://hdl.handle.net/10754/666931
dc.description.abstractCellular homeostasis plays a critical role in how an organism will develop and age. Disruption of this fragile equilibrium is often associated with health degradation and ultimately, death. Reactive oxygen species (ROS) have been closely associated with health decline and neurological disorders, such as Alzheimer's disease or Parkinson's disease. ROS were first identified as by-products of the cellular activity, mainly mitochondrial respiration, and their high reactivity is linked to a disruption of macromolecules such as proteins, lipids and DNA. More recent research suggests more complex function of ROS, reaching far beyond the cellular dysfunction. ROS are active actors in most of the signaling cascades involved in cell development, proliferation and survival, constituting important second messengers. In the brain, their impact on neurons and astrocytes has been associated with synaptic plasticity and neuron survival. This review provides an overview of ROS function in cell signaling in the context of aging and degeneration in the brain and guarding the fragile balance between health and disease.
dc.description.sponsorshipThis work was funded by the King Abdullah University of Science and Technology.
dc.publisherSpringer Nature
dc.relation.urlhttp://link.springer.com/10.1007/s11064-020-03208-7
dc.rightsThis is an open access article distributed under the terms of the Creative Commons CC BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleReactive Oxygen Species: Beyond Their Reactive Behavior.
dc.typeArticle
dc.contributor.departmentBiological and Environmental Science and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentKAUST Smart Health Initiative
dc.contributor.departmentOffice of the President
dc.identifier.journalNeurochemical research
dc.eprint.versionPublisher's Version/PDF
kaust.personTauffenberger, Arnaud
kaust.personMagistretti, Pierre J.
dc.date.accepted2020-12-15
refterms.dateFOA2021-01-19T10:59:45Z
dc.date.published-online2021-01-13
dc.date.published-print2021-01


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This is an open access article distributed under the terms of the Creative Commons CC BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as This is an open access article distributed under the terms of the Creative Commons CC BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.