KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Permanent link to this recordhttp://hdl.handle.net/10754/666931
MetadataShow full item record
AbstractCellular homeostasis plays a critical role in how an organism will develop and age. Disruption of this fragile equilibrium is often associated with health degradation and ultimately, death. Reactive oxygen species (ROS) have been closely associated with health decline and neurological disorders, such as Alzheimer's disease or Parkinson's disease. ROS were first identified as by-products of the cellular activity, mainly mitochondrial respiration, and their high reactivity is linked to a disruption of macromolecules such as proteins, lipids and DNA. More recent research suggests more complex function of ROS, reaching far beyond the cellular dysfunction. ROS are active actors in most of the signaling cascades involved in cell development, proliferation and survival, constituting important second messengers. In the brain, their impact on neurons and astrocytes has been associated with synaptic plasticity and neuron survival. This review provides an overview of ROS function in cell signaling in the context of aging and degeneration in the brain and guarding the fragile balance between health and disease.
CitationTauffenberger, A., & Magistretti, P. J. (2021). Reactive Oxygen Species: Beyond Their Reactive Behavior. Neurochemical Research. doi:10.1007/s11064-020-03208-7
SponsorsThis work was funded by the King Abdullah University of Science and Technology.
PublisherSpringer Science and Business Media LLC
Except where otherwise noted, this item's license is described as This is an open access article distributed under the terms of the Creative Commons CC BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Free radicals and antioxidants in normal physiological functions and human disease.
- Authors: Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J
- Issue date: 2007
- Oxidative Stress and the Aging Brain: From Theory to Prevention
- Authors: Gemma C, Vila J, Bachstetter A, Bickford PC, Riddle DR
- Issue date: 2007
- Reactive Oxygen Species Modulate Activity-Dependent AMPA Receptor Transport in <i>C. elegans</i>.
- Authors: Doser RL, Amberg GC, Hoerndli FJ
- Issue date: 2020 Sep 23
- Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia.
- Authors: Calabrese V, Lodi R, Tonon C, D'Agata V, Sapienza M, Scapagnini G, Mangiameli A, Pennisi G, Stella AM, Butterfield DA
- Issue date: 2005 Jun 15
- Reactive oxygen species in health and disease.
- Authors: Datta K, Sinha S, Chattopadhyay P
- Issue date: 2000 Nov-Dec