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Tauffenberger-Magistretti2021_Article_ReactiveOxygenSpeciesBeyondThe (1).pdf
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ArticleKAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Program
Date
2021-01-13Submitted Date
2020-04-22Permanent link to this record
http://hdl.handle.net/10754/666931
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Cellular homeostasis plays a critical role in how an organism will develop and age. Disruption of this fragile equilibrium is often associated with health degradation and ultimately, death. Reactive oxygen species (ROS) have been closely associated with health decline and neurological disorders, such as Alzheimer's disease or Parkinson's disease. ROS were first identified as by-products of the cellular activity, mainly mitochondrial respiration, and their high reactivity is linked to a disruption of macromolecules such as proteins, lipids and DNA. More recent research suggests more complex function of ROS, reaching far beyond the cellular dysfunction. ROS are active actors in most of the signaling cascades involved in cell development, proliferation and survival, constituting important second messengers. In the brain, their impact on neurons and astrocytes has been associated with synaptic plasticity and neuron survival. This review provides an overview of ROS function in cell signaling in the context of aging and degeneration in the brain and guarding the fragile balance between health and disease.Citation
Tauffenberger, A., & Magistretti, P. J. (2021). Reactive Oxygen Species: Beyond Their Reactive Behavior. Neurochemical Research. doi:10.1007/s11064-020-03208-7Sponsors
This work was funded by the King Abdullah University of Science and Technology.Publisher
Springer Science and Business Media LLCJournal
Neurochemical researchPubMed ID
33439432Additional Links
http://link.springer.com/10.1007/s11064-020-03208-7ae974a485f413a2113503eed53cd6c53
10.1007/s11064-020-03208-7
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Except where otherwise noted, this item's license is described as This is an open access article distributed under the terms of the Creative Commons CC BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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