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dc.contributor.authorAlzanbaki, Hamzah
dc.contributor.authorMoretti, Manola
dc.contributor.authorHauser, Charlotte
dc.date.accessioned2021-01-05T07:48:35Z
dc.date.available2021-01-05T07:48:35Z
dc.date.issued2021-01-01
dc.date.submitted2020-10-19
dc.identifier.citationAlzanbaki, H., Moretti, M., & Hauser, C. A. E. (2021). Engineered Microgels—Their Manufacturing and Biomedical Applications. Micromachines, 12(1), 45. doi:10.3390/mi12010045
dc.identifier.issn2072-666X
dc.identifier.doi10.3390/mi12010045
dc.identifier.urihttp://hdl.handle.net/10754/666816
dc.description.abstractMicrogels are hydrogel particles with diameters in the micrometer scale that can be fabricated in different shapes and sizes. Microgels are increasingly used for biomedical applications and for biofabrication due to their interesting features, such as injectability, modularity, porosity and tunability in respect to size, shape and mechanical properties. Fabrication methods of microgels are divided into two categories, following a top-down or bottom-up approach. Each approach has its own advantages and disadvantages and requires certain sets of materials and equipments. In this review, we discuss fabrication methods of both top-down and bottom-up approaches and point to their advantages as well as their limitations, with more focus on the bottom-up approaches. In addition, the use of microgels for a variety of biomedical applications will be discussed, including microgels for the delivery of therapeutic agents and microgels as cell carriers for the fabrication of 3D bioprinted cell-laden constructs. Microgels made from well-defined synthetic materials with a focus on rationally designed ultrashort peptides are also discussed, because they have been demonstrated to serve as an attractive alternative to much less defined naturally derived materials. Here, we will emphasize the potential and properties of ultrashort self-assembling peptides related to microgels.
dc.description.sponsorshipThe work was supported by funding from King Abdullah University of Science and Technology (KAUST).
dc.publisherMDPI AG
dc.relation.urlhttps://www.mdpi.com/2072-666X/12/1/45
dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleEngineered Microgels—Their Manufacturing and Biomedical Applications
dc.typeArticle
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.identifier.journalMicromachines
dc.eprint.versionPublisher's Version/PDF
dc.identifier.volume12
dc.identifier.issue1
dc.identifier.pages45
kaust.personAlzanbaki, Hamzah
kaust.personMoretti, Manola
kaust.personHauser, Charlotte
dc.date.accepted2020-12-14
refterms.dateFOA2021-01-05T07:49:21Z


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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
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