An RCT of acute health effects in COPD-patients after passive vape exposure from e-cigarettes
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ArticleAuthors
Rosenkilde Laursen, Karin
Bønløkke, Jakob Hjort

Bendstrup, Elisabeth

Bilde, Merete

Glasius, Marianne

Heitmann Gutzke, Vibeke
Puthukkadan Moosakutty, Shamjad

Olin, Anna-Carin
Ravn, Peter
Østergaard, Kirsten
Sigsgaard, Torben

Date
2020-12-24Submitted Date
2020-08-21Permanent link to this record
http://hdl.handle.net/10754/666793
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Background: E-cigarette use has been shown to have short-term acute effects among active users but less is known of the acute passive effects, particularly among individuals with existing respiratory diseases. Objective: To investigate local and systemic effects of short-term passive vape exposure among patients with mild or moderate chronic obstructive pulmonary disease (COPD). Methods: In a double-blinded crossover study 16 non-smoking COPD-patients (mean age 68) were randomly exposed for 4 h to passive vape (median PM2.5: 18 µg/m3 (range: 8–333)) and clean air (PM2.5 < 6 µg/m3) separated by 14 days. Particles were measured using an ultrafine particle counter (P-TRAK) and a scanning mobility particle sizer (SMPS). Health effects including Surfactant Protein-A (SP-A) and albumin in exhaled air, spirometry, FeNO, and plasma proteins were evaluated before, right after, and 24 hours after exposure. Participants reported symptoms throughout exposure sessions. Data were analyzed using mixed models. Results: SP-A in exhaled air was negatively affected by exposure to vape and several plasma proteins increased significantly. Throat irritation was more pronounced during passive vape exposure, while FVC and FEV1 decreased, however, not significantly. Conclusions: SP-A in exhaled air and some plasma proteins were affected by passive vape in patients with COPD indicating inflammation, showing that passive vape exposure is potentially harmful.Citation
Rosenkilde Laursen, K., Bønløkke, J. H., Bendstrup, E., Bilde, M., Glasius, M., Heitmann Gutzke, V., … Sigsgaard, T. (2020). An RCT of acute health effects in COPD-patients after passive vape exposure from e-cigarettes. European Clinical Respiratory Journal, 8(1), 1861580. doi:10.1080/20018525.2020.1861580Sponsors
We are thankful to PExA AB (Göteborg, Sweden) for lending us the PExA® instrument and performing the analysis, and to Nightingale Health Ltd (Helsinki, Finland) for analyzing the blood samples. We would like to thank K.V. Kristensen for skillful assistance in measuring the particle exposure and R.B.Madsen and J.K. Christensen (Dept. of Chemistry, Aarhus University) for their contributions to chemical analyses. We particularly thank the subjects for their participation in the study.Publisher
Informa UK LimitedAdditional Links
https://www.tandfonline.com/doi/full/10.1080/20018525.2020.1861580ae974a485f413a2113503eed53cd6c53
10.1080/20018525.2020.1861580
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