On the N-Arylation of Acetamide Using 2-, 3- and 1’-Substituted Iodoferrocenes**
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2021-12-22
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ArticleAuthors
Kadari, LingaswamyErb, William

Halauko, Yury S.
Ivashkevich, Oleg A.
Matulis, Vadim E.
Lyakhov, Dmitry

Roisnel, Thierry
Radha Krishna, Palakodety
Mongin, Florence
KAUST Department
Visual Computing Center (VCC)Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Date
2020-12-22Embargo End Date
2021-12-22Submitted Date
2020-09-28Permanent link to this record
http://hdl.handle.net/10754/666657
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Various 2-, 3- and 1’-substituted iodoferrocenes were reacted with acetamide in the presence of copper(I) iodide (1 equiv), N,N’-dimethylethylenediamine (1 equiv), tripotassium phosphate (2 equiv) in dioxane at 90 °C for 14 h, and allowed a large range of original 1,2-, 1,3- and 1,1’-disubstituted ferrocenes to be obtained. The results were compared as a function of the substituent and its position on the ring. DFT calculations revealed higher activation barrier for the oxidative addition in the ferrocene series when compared with classical planar aromatics. Structure-property relationships were applied to rationalize the reactivity of the different iodoferrocenes.Citation
Kadari, L., Erb, W., Halauko, Y. S., Ivashkevich, O. A., Matulis, V. E., Lyakhov, D., … Mongin, F. (2020). On the N -Arylation of Acetamide Using 2-, 3- and 1’-Substituted Iodoferrocenes**. European Journal of Inorganic Chemistry. doi:10.1002/ejic.202000904Publisher
WileyAdditional Links
https://onlinelibrary.wiley.com/doi/10.1002/ejic.202000904ae974a485f413a2113503eed53cd6c53
10.1002/ejic.202000904