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dc.contributor.authorSlater, Luke T.
dc.contributor.authorGkoutos, Georgios V.
dc.contributor.authorSchofield, Paul N.
dc.contributor.authorHoehndorf, Robert
dc.date.accessioned2020-12-22T05:53:06Z
dc.date.available2020-12-22T05:53:06Z
dc.date.issued2016-01-01
dc.identifier.issn1613-0073
dc.identifier.urihttp://hdl.handle.net/10754/666583
dc.description.abstractMIREOT is a mechanism for the selective re-use of individual ontology classes in other ontologies. Designed to minimise effort and to support orthogonality, it is now in widespread use. The consequences for ontology integrity and automated reasoning of using the MIREOT mechanism have so far not been fully assessed. In this paper, we perform an analysis of the Experimental Factor Ontology (EFO), an ontology which uses the MIREOT process to gather classes from a large range of other ontologies. Our study examines the effect of combining EFO with the ontologies it references by actually importing them into the EFO. We then evaluate the consistency and status of the combined ontologies. Through our investigation, we reveal that EFO in combination with all its referenced ontologies is logically inconsistent. Furthermore, when EFO is individually combined with many of the ontologies it references, we find a large number of unsatisfiable classes. These results demonstrate a potential problem within a major ontological ecosystem, and reveals possible disadvantages to the use of the MIREOT system for developing ontologies.
dc.description.sponsorshipLTS and GVG were supported by the National Science Foundation (grant IOS:1340112). RH was supported by funding from the King Abdullah University of Science and Technology.
dc.publisherCEUR-WS
dc.relation.urlhttps://core.ac.uk/download/pdf/267298572.pdf
dc.rightsArchived with thanks to CEUR-WS
dc.titleTo MIREOT or not to MIREOT? A case study of the impact of using MIREOT in the Experimental Factor Ontology (EFO)
dc.typeConference Paper
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentComputer Science Program
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.conference.date2016-08-01 to 2016-08-04
dc.conference.name2016 Joint International Conference on Biological Ontology and BioCreative - Food, Nutrition, Health and Environment for the 9 Billion, ICBO-BioCreative 2016
dc.conference.locationCorvallis, OR, USA
dc.eprint.versionPre-print
dc.contributor.institutionCollege of Medical and Dental Sciences, Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, B15 2TT, United Kingdom
dc.contributor.institutionInstitute of Translational Medicine, University Hospitals Birmingham NHS Foundation Trust, B15 2TT, United Kingdom
dc.contributor.institutionDepartment of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, CB2 3EG, United Kingdom
dc.identifier.volume1747
kaust.personHoehndorf, Robert
dc.identifier.eid2-s2.0-85018772965


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