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dc.contributor.authorGuan, Qingtian
dc.contributor.authorUmmels, Roy
dc.contributor.authorBen Rached, Fathia
dc.contributor.authorAlzahid, Yara
dc.contributor.authorAmini, Mohammad S
dc.contributor.authorAdroub, Sabir A
dc.contributor.authorVan Ingen, Jakko
dc.contributor.authorBitter, Wilbert
dc.contributor.authorAbdallah, Abdallah M
dc.contributor.authorPain, Arnab
dc.date.accessioned2020-12-21T07:14:20Z
dc.date.available2020-12-21T07:14:20Z
dc.date.issued2019-11-26
dc.identifier.urihttp://hdl.handle.net/10754/666535
dc.description.abstractMycobacterium kansasii shows a close phylogenetic relationship with Mycobacterium tuberculosis which causes more than 1.5 million deaths per year in recent years. Seven subtypes (I-VII) have been identified using molecular biology approach while Type I-V were the most commonly discovered, and subtype I represents the most frequent isolates contributing to human disease. To investigate the genotypes and pathogenicity components of M. kansasii, we have sequenced the genome of M. kansasii subtypes KAUST I-V with PacBio sequencing technique to describe complete and accurate genomes, then undertook comparative genomics and a transcriptomic approach. We proposed that the “subtypes” of M. kansasii should be considered as different species and developed the genotyping primers for Type I-V. We have also found out several potential virulence factors and determined the pathogenic role of the espACD operon in M. kansasii.
dc.publisherNCBI
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/bioproject/?term=PRJEB32175
dc.titleComparative genomic and transcriptome analysis of M. kansasii subtypes provides new insights on its taxonomy and pathogenicity
dc.typeBioproject
dc.typeDataset
dc.contributor.departmentBioscience Program
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentPathogen Genomics Laboratory, BESE Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
dc.contributor.institutionDepartment of Medical Microbiology and Infection Control, Amsterdam University Medical Centers, Amsterdam, Netherlands.
dc.contributor.institutionDepartment of Medical Microbiology, Radboud UMC Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.
dc.contributor.institutionDepartment of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar.
kaust.personGuan, Qingtian
kaust.personBen Rached, Fathia
kaust.personAlzahid, Yara
kaust.personAmini, Mohammad S
kaust.personAdroub, Sabir A
kaust.personPain, Arnab
dc.relation.issupplementtoDOI:10.3389/fcimb.2020.00122
display.relations<b>Is Supplement To:</b><br/> <ul><li><i>[Article]</i> <br/> Guan, Q., Ummels, R., Ben-Rached, F., Alzahid, Y., Amini, M. S., Adroub, S. A., … Pain, A. (2020). Comparative Genomic and Transcriptomic Analyses of Mycobacterium kansasii Subtypes Provide New Insights Into Their Pathogenicity and Taxonomy. Frontiers in Cellular and Infection Microbiology, 10. doi:10.3389/fcimb.2020.00122. DOI: <a href="https://doi.org/10.3389/fcimb.2020.00122" >10.3389/fcimb.2020.00122</a> Handle: <a href="http://hdl.handle.net/10754/662501" >10754/662501</a></a></li></ul>
dc.identifier.bioprojectPRJEB32175


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