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    Microfluidics integrated n-type organic electrochemical transistor for metabolite sensing

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    Name:
    Koklu_et al_Sensors and Actuators B final.pdf
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    1.067Mb
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    PDF
    Description:
    Accepted manuscript
    Embargo End Date:
    2022-12-08
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    Name:
    Koklu et al_Supporting Information_Sensors and Actuators B final.pdf
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    1.038Mb
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    PDF
    Description:
    supporting Information
    Embargo End Date:
    2022-12-08
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    Type
    Article
    Authors
    Koklu, Anil
    Ohayon, David cc
    Wustoni, Shofarul cc
    Hama, Adel
    Chen, Xingxing cc
    McCulloch, Iain cc
    Inal, Sahika cc
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    KAUST Solar Center (KSC)
    Physical Science and Engineering (PSE) Division
    Chemical Science Program
    KAUST Grant Number
    OSR-2018-CRG7-3709
    OSR-2015-Sensors-2719
    Date
    2020-12-01
    Embargo End Date
    2022-12-08
    Submitted Date
    2020-08-30
    Permanent link to this record
    http://hdl.handle.net/10754/666507
    
    Metadata
    Show full item record
    Abstract
    The organic electrochemical transistor (OECT) can translate biochemical binding events between a recognition unit and its analyte into an electrical signal. We present an OECT comprising an n-type (electron transporting) conjugated polymer-based channel and lateral gate electrode functionalized with the enzyme, glucose oxidase. The device is integrated with a microfluidic system for real-time glucose monitoring in a flow-through manner. The n-type polymer has direct electrical communication with glucose oxidase, allowing glucose detection while surpassing hydrogen peroxide production. The microfluidic-integrated OECT shows superior features compared to its microfluidic-free counterpart, including higher current and transconductance values as well as improved signal-to-noise (SNR) ratios, which enhances the sensor sensitivity and its detection limit. Thanks to the low noise endowed by the integrated microfluidics, the gate current changes upon metabolite recognition could be resolved, revealing that while the relative changes in gate and drain currents are similar, the drain current output has a higher SNR. This is the first demonstration of the integration of a microfluidic system with an n-type accumulation mode OECT for real-time enzymatic metabolite detection. The microfluidic-integrated design provides new insights into the mechanisms leading to high sensor sensitivities, crucial for the development of portable and autonomous lab-on-a-chip technologies.
    Citation
    Koklu, A., Ohayon, D., Wustoni, S., Hama, A., Chen, X., McCulloch, I., & Inal, S. (2021). Microfluidics integrated n-type organic electrochemical transistor for metabolite sensing. Sensors and Actuators B: Chemical, 329, 129251. doi:10.1016/j.snb.2020.129251
    Sponsors
    This publication is based upon work supported by the King Abdullah University of Science and Technology (KAUST) Office of Sponsored Research (OSR) under Award No. OSR-2018-CRG7-3709 and OSR-2015-Sensors-2719.
    Publisher
    Elsevier BV
    Journal
    Sensors and Actuators, B: Chemical
    DOI
    10.1016/j.snb.2020.129251
    Additional Links
    https://linkinghub.elsevier.com/retrieve/pii/S0925400520315914
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.snb.2020.129251
    Scopus Count
    Collections
    Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program; Physical Science and Engineering (PSE) Division; Chemical Science Program; KAUST Solar Center (KSC)

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