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    COVID-19 and Beyond: A Call for Action and Audacious Solidarity to All the Citizens and Nations, It Is Humanity’s Fight

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    COVID19 and Beyond A Call for Action and Audacious Solidarity to All the Citizens and Nations It Is Humanity’s Fight.pdf
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    2.405Mb
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    PDF
    Description:
    Accepted manuscript
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    Type
    Article
    Authors
    Auffray, Charles
    Balling, Rudi
    Blomberg, Niklas
    BONALDO, MYRNA
    Boutron, Bertrand
    Brahmachari, Samir
    Bréchot, Christian
    Cesario, Alfredo
    Chen, Sai-Juan
    Clément, Karine
    Danilenko, Daria
    Di Meglio, Alberto
    Gelemanovic, Andrea
    Goble, Carole
    Gojobori, Takashi cc
    Goldman, Jason D
    Goldman, Michel
    Guo, Yi-Ke
    Heath, James
    Hood, Leroy
    Hunter, Peter
    Jin, Li
    Kitano, Hiroaki
    Knoppers, Bartha Maria
    Lancet, Doron
    Larue, Catherine
    Lathrop, Mark
    Laville, Martine
    Lindner, Ariel B
    Magnan, Antoine
    Metspalu, Andres
    Morin, Edgar
    Ng, Lisa F.P.
    Nicod, Laurent
    Noble, Denis
    Nottale, Laurent
    Nowotny, Helga
    Ochoa, Theresa
    Okeke, Iruna
    Oni, Tolu
    Openshaw, Peter
    Oztürk, Mehmet
    Palkonen, Susanna
    Paweska, Janusz
    Pison, Christophe
    Polymeropoulos, Mihael
    Pristipino, Christian
    Protzer, Ulrike
    Roca, Josep
    Rozman, Damjana
    Santolini, Marc
    Sanz, Ferran
    Scambia, Giovanni
    Segal, Eran
    Serageldin, Ismail
    Soares, Marcelo Bento
    Sterk, Peter
    Sugano, Sumio
    Superti-Furga, Giulio
    Supple, David
    Tegnér, Jesper
    Uhlen, Mathias
    Urbani, Andrea
    Valencia, Alfonso
    Valentini, Vincenzo
    van der Werf, Sylvie
    Vinciguerra, Manlio
    Wolkenhauer, Olaf
    Wouters, Emiel
    KAUST Department
    Bioscience Program
    Computational Bioscience Research Center (CBRC)
    Biological and Environmental Sciences and Engineering (BESE) Division
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Date
    2020-06-26
    Permanent link to this record
    http://hdl.handle.net/10754/666312
    
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    Abstract
    SARS-CoV-2 belongs to a subgroup of coronaviruses rampant in bats for centuries. It has caused the COVID-19 pandemic. Most patients recover, but a minority of severe cases experience acute respiratory distress or an inflammatory storm devastating many organs that can lead to patient death. The spread of SARS-CoV-2 has been facilitated by the increasing intensity of air travel, urban congestion and human contact during the last half century. Until therapies and vaccines are available, tests for virus and exposure, confinement measures and physical distancing have helped curb the pandemic. The COVID-19 pandemic calls for safeguards and remediation measures through a systemic response. A myriad of selforganizing initiatives by scientists and citizens is developing an advanced collective intelligence response to the coronavirus crisis. Their integration forms Olympiads of Solidarity and Health. Their ability to optimize our response to COVID-19 could serve as a model to trigger a global metamorphosis of our societies with far-reaching consequences for attacking fundamental challenges facing humanity in the 21st century. For COVID-19 and these other challenges, there is no alternative but action. Meeting in Paris in 2003, we set out to "rethink research to understand life and improve health." We have now formed an international coalition of academia and industry ecosystems taking a systems medicine approach to understanding COVID-19 by thoroughly characterizing viruses, patients and populations during the pandemic, using openly shared tools. All results will be publicly available with no initial claims for intellectual property rights. This World Alliance for Health and Wellbeing will catalyze the creation of medical and health products such as diagnostic tests, drugs and vaccines that become common goods accessible to all, while seeking further alliances with civil society to bridge with socio-ecological and technological approaches that characterise urban systems, for a collective response to future health emergencies.
    Citation
    Auffray, C., Balling, R., Blomberg, N., BONALDO, M., Boutron, B., Brahmachari, S., … Clément, K. (2020). COVID-19 and Beyond: A Call for Action and Audacious Solidarity to All the Citizens and Nations, It Is Humanity’s Fight. SSRN Electronic Journal. doi:10.2139/ssrn.3630412
    Sponsors
    CA wrote the initial draft of the paper; all authors provided input into and approved the final version. We thank Bertrand De Meulder for help in formatting the references, colleagues and citizens for useful comments on the manuscript.
    This work was supported during its preparation phases by the State Key Laboratory of Medical Genomics, Overseas Expertise Introduction Project for Discipline Innovation (111 Project, B17029) to SJC, LH, CA; European Union grants CASyM (FP7-n°305033) to CA, RB, JR, DR, DS, JT, OW; eTRIKS (IMI-1-n°115446) to CA, RB, YG; PREPARE (FP7-n°602525) to CA, PO, SV; and initial funds in support of the deep phenotyping clinical study from philanthropic donors, Gilead, Merck and Novartis to JG, JH, LH; the Ricerca Corrente Program by the Italian Ministry of Health to AC, CPr, GS, AU, VV; the National Megaprojects of China for Infectious Diseases (2017ZX10103009-001, 2018ZX10305409-001-005), Double Firstclass projects from the Ministry of Education to the National Research Center for Translational Medicine Shanghai to SJC; Shanghai Municipal Science and Technology Major Project (2017SHZDZX01) to LJ. The funders had no role in the preparation or submission of the manuscript.
    Publisher
    SSRN
    DOI
    10.2139/ssrn.3630412
    10.12688/f1000research.26098.1
    Additional Links
    https://www.ssrn.com/abstract=3630412
    ae974a485f413a2113503eed53cd6c53
    10.2139/ssrn.3630412
    Scopus Count
    Collections
    Biological and Environmental Sciences and Engineering (BESE) Division; Preprints; Bioscience Program; Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

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