Recent Advances in Nickel-Catalyzed C-Heteroatom Cross-Coupling Reactions under Mild Conditions via Facilitated Reductive Elimination.
KAUST DepartmentKAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
King Abdullah University of Science and Technology KAUST Catalysis Center SAUDI ARABIA
Chemical Science Program
KAUST Grant NumberURF/1/4025
Embargo End Date2021-11-30
Permanent link to this recordhttp://hdl.handle.net/10754/666223
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AbstractThe formation of C-heteroatom bonds represents an important type of bond-forming reaction in organic synthesis and often provides a fast and efficient access to privileged structures found in pharmaceuticals, agrochemical and materials. In contrast to conventional Pd- or Cu-catalyzed C-heteroatom cross-couplings under high-temperature conditions, recent advances in homo- and heterogeneous Ni-catalyzed C-heteroatom formations under mild conditions are particularly attractive from the standpoint of sustainability and practicability. The generation of Ni III and excited Ni II intermediates facilitate the reductive elimination step to achieve mild cross-couplings. This minireview provides an overview of the state-of-the-art approaches for mild C-heteroatom bond formations highlights the developments in photoredox and nickel dual catalysis involving SET and energy transfer processes; photoexcited nickel cataylsis; electro and nickel dual catalysis; heterogeneous photoredox and nickel dual catalysis involving graphitic carbon nitride (mpg-CN), metal organic frameworks (MOFs) or semiconductor quantum dots (QDs); as well as more conventional zinc and nickel dual catalyzed reactions.
CitationZhu, C., Yue, H., Jia, J., & Rueping, M. (2020). Recent Advances in Nickel-Catalyzed C-Heteroatom Cross-Coupling Reactions under Mild Conditions via Facilitated Reductive Elimination. Angewandte Chemie International Edition. doi:10.1002/anie.202013852
SponsorsThis work was financially supported by the King Abdullah University of Science and Technology (KAUST), Saudi Arabia, Office of Sponsored Research (URF/1/4025).
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