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dc.contributor.authorMourier, Tobias
dc.contributor.authorSadykov, Mukhtar
dc.contributor.authorCarr, Michael J
dc.contributor.authorGonzalez, Gabriel
dc.contributor.authorHall, William W
dc.contributor.authorPain, Arnab
dc.date.accessioned2020-11-30T11:48:16Z
dc.date.available2020-11-30T11:48:16Z
dc.date.issued2020-11-05
dc.date.submitted2020-10-08
dc.identifier.citationMourier, T., Sadykov, M., Carr, M. J., Gonzalez, G., Hall, W. W., & Pain, A. (2020). Host-directed editing of the SARS-CoV-2 genome. Biochemical and Biophysical Research Communications. doi:10.1016/j.bbrc.2020.10.092
dc.identifier.issn0006-291X
dc.identifier.pmid33234239
dc.identifier.doi10.1016/j.bbrc.2020.10.092
dc.identifier.urihttp://hdl.handle.net/10754/666152
dc.description.abstractThe extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and reactive oxygen species (ROS), and discuss their potential implications on SARS-CoV-2 evolution.
dc.description.sponsorshipWe thank all laboratories which have contributed sequences to the GISAID database. This work was supported by funding from King Abdullah University of Science and Technology (KAUST), Office of Sponsored Research (OSR). Work in AP’s laboratory is supported by the KAUST faculty baseline fund (BAS/1/1020-01-01) and the R3T initiative of KAUST.
dc.publisherElsevier BV
dc.relation.urlhttps://linkinghub.elsevier.com/retrieve/pii/S0006291X20320210
dc.rightsThis is an open access article under the CC BY-NC-ND license.
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleHost-directed editing of the SARS-CoV-2 genome.
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience
dc.contributor.departmentBioscience Program
dc.identifier.journalBiochemical and biophysical research communications
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionNational Virus Reference Laboratory (NVRL), School of Medicine, University College Dublin, Belfield, D04 V1W8, Dublin, Ireland.
dc.contributor.institutionResearch Center for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, N20 W10 Kita-ku, Sapporo, 001-0020, Japan.
dc.contributor.institutionGlobal Virus Network (GVN), 801 W. Baltimore St., Baltimore, MD, 21201, USA.
kaust.personMourier, Tobias
kaust.personSadykov, Mukhtar
kaust.personPain, Arnab
kaust.grant.numberBAS/1/1020-01-01
dc.date.accepted2020-10-26
refterms.dateFOA2020-11-30T11:49:07Z
kaust.acknowledged.supportUnitOffice of Sponsored Research (OSR)
dc.date.published-online2020-11-05
dc.date.published-print2021-01


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