Host-directed editing of the SARS-CoV-2 genome.
Type
ArticleAuthors
Mourier, TobiasSadykov, Mukhtar
Carr, Michael J
Gonzalez, Gabriel
Hall, William W
Pain, Arnab
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience
Bioscience Program
KAUST Grant Number
BAS/1/1020-01-01Date
2020-11-05Online Publication Date
2020-11-05Print Publication Date
2021-01Submitted Date
2020-10-08Permanent link to this record
http://hdl.handle.net/10754/666152Metadata
Show full item recordAbstract
The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and reactive oxygen species (ROS), and discuss their potential implications on SARS-CoV-2 evolution.Citation
Mourier, T., Sadykov, M., Carr, M. J., Gonzalez, G., Hall, W. W., & Pain, A. (2020). Host-directed editing of the SARS-CoV-2 genome. Biochemical and Biophysical Research Communications. doi:10.1016/j.bbrc.2020.10.092Sponsors
We thank all laboratories which have contributed sequences to the GISAID database. This work was supported by funding from King Abdullah University of Science and Technology (KAUST), Office of Sponsored Research (OSR). Work in AP’s laboratory is supported by the KAUST faculty baseline fund (BAS/1/1020-01-01) and the R3T initiative of KAUST.Publisher
Elsevier BVPubMed ID
33234239Additional Links
https://linkinghub.elsevier.com/retrieve/pii/S0006291X20320210Scopus Count
Except where otherwise noted, this item's license is described as This is an open access article under the CC BY-NC-ND license.