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dc.contributor.authorNoro, Yukihiko
dc.contributor.authorShimizu, Hiroshi
dc.contributor.authorMineta, Katsuhiko
dc.contributor.authorGojobori, Takashi
dc.date.accessioned2021-05-30T06:03:56Z
dc.date.available2020-11-24T13:16:46Z
dc.date.available2021-05-30T06:03:56Z
dc.date.issued2021-05-24
dc.date.submitted2020-11-22
dc.identifier.citationNoro, Y., Shimizu, H., Mineta, K., & Gojobori, T. (2021). A single neuron subset governs a single coactive neuron circuit in Hydra vulgaris, representing a possible ancestral feature of neural evolution. Scientific Reports, 11(1). doi:10.1038/s41598-021-89325-x
dc.identifier.issn2045-2322
dc.identifier.pmid34031445
dc.identifier.doi10.1038/s41598-021-89325-x
dc.identifier.urihttp://hdl.handle.net/10754/666101
dc.description.abstractAbstractThe last common ancestor of Bilateria and Cnidaria is believed to be one of the first animals to develop a nervous system over 500 million years ago. Many of the genes involved in the neural function of the advanced nervous system in Bilateria are well conserved in Cnidaria. Thus, the cnidarian Hydra vulgaris is a good model organism for the study of the putative primitive nervous system in its last common ancestor. The diffuse nervous system of Hydra consists of several peptidergic neuron subsets. However, the specific functions of these subsets remain unclear. Using calcium imaging, here we show that the neuron subsets that express neuropeptide, Hym-176, function as motor circuits to evoke longitudinal contraction. We found that all neurons in a subset defined by the Hym-176 gene (Hym-176A) or its paralogs (Hym-176B) expression are excited simultaneously, followed by longitudinal contraction. This indicates not only that these neuron subsets have a motor function but also that a single molecularly defined neuron subset forms a single coactive circuit. This is in contrast with the bilaterian nervous system, where a single molecularly defined neuron subset harbors multiple coactive circuits, showing a mixture of neurons firing with different timings. Furthermore, we found that the two motor circuits, one expressing Hym-176B in the body column and the other expressing Hym-176A in the foot, are coordinately regulated to exert region-specific contraction. Our results demonstrate that one neuron subset is likely to form a monofunctional circuit as a minimum functional unit to build a more complex behavior in Hydra. This simple feature (one subset, one circuit, one function) found in Hydra may represent the simple ancestral condition of neural evolution.
dc.description.sponsorshipThis work was supported through funding from King Abdullah University of Science and Technology (KAUST) under award numbers BAS/1/1059/01/01 and URF/1/1976/03/01.
dc.publisherSpringer Science and Business Media LLC
dc.relation.urlhttp://www.nature.com/articles/s41598-021-89325-x
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleA single neuron subset governs a single coactive neuron circuit in Hydra vulgaris, representing a possible ancestral feature of neural evolution
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentBioscience Program
dc.identifier.journalScientific Reports
dc.identifier.pmcidPMC8144215
dc.eprint.versionPublisher's Version/PDF
dc.identifier.volume11
dc.identifier.issue1
kaust.personNoro, Yukihiko
kaust.personShimizu, Hiroshi
kaust.personMineta, Katsuhiko
kaust.personGojobori, Takashi
kaust.grant.numberBAS/1/1059/01/01
kaust.grant.numberURF/1/1976/03/01
dc.date.accepted2021-04-23
refterms.dateFOA2020-11-24T13:18:02Z
kaust.acknowledged.supportUnitBAS


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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
Except where otherwise noted, this item's license is described as This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
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