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dc.contributor.authorPiwonski, Hubert Marek
dc.contributor.authorWang, Yang
dc.contributor.authorLi, Wei
dc.contributor.authorMichinobu, Tsuyoshi
dc.contributor.authorHabuchi, Satoshi
dc.date.accessioned2020-11-23T11:07:54Z
dc.date.available2020-11-23T11:07:54Z
dc.date.issued2020-11-18
dc.date.submitted2020-09-10
dc.identifier.citationPiwoński, H., Wang, Y., Li, W., Michinobu, T., & Habuchi, S. (2020). Millimeter-Deep Detection of Single Shortwave-Infrared-Emitting Polymer Dots through Turbid Media. Nano Letters. doi:10.1021/acs.nanolett.0c03675
dc.identifier.issn1530-6984
dc.identifier.issn1530-6992
dc.identifier.pmid33206524
dc.identifier.doi10.1021/acs.nanolett.0c03675
dc.identifier.urihttp://hdl.handle.net/10754/666078
dc.description.abstractFluorescence imaging at longer wavelengths, especially in the shortwave-infrared (SWIR: 1000-1700 nm) region, leads to a substantial decrease in light attenuation, scattering, and background autofluorescence, thereby enabling enhanced penetration into biological tissues. The limited selection of fluorescent probes is a major bottleneck in SWIR fluorescence imaging. Here, we develop SWIR-emitting nanoparticles composed of donor-acceptor-type conjugated polymers. The bright SWIR fluorescence of the polymer dots (primarily attributable to their large absorption cross-section and high fluorescence saturation intensity (as high as 113 kW·cm-2)) enables the unprecedented detection of single particles as small as 14 nm through millimeter-thick turbid media. Unlike most SWIR-emitting nanomaterials, which have an excited-state lifetime in the range of microseconds to milliseconds, our polymer dots exhibit a subnanosecond excited-state lifetime. These characteristics enable us to demonstrate new time-gated single-particle imaging with a high signal-to-background ratio. These findings expand the range of potential applications of single-particle deep-tissue imaging.
dc.description.sponsorshipThis study was supported by King Abdullah University of Science and Technology (KAUST) and the KAUST Office of Sponsored Research (OSR) under Award No. OSR-2016-2967-CRG5.
dc.publisherAmerican Chemical Society (ACS)
dc.relation.urlhttps://pubs.acs.org/doi/10.1021/acs.nanolett.0c03675
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Nano Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.nanolett.0c03675.
dc.titleMillimeter-Deep Detection of Single Shortwave-Infrared-Emitting Polymer Dots through Turbid Media
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.identifier.journalNano Letters
dc.rights.embargodate2021-11-18
dc.eprint.versionPost-print
dc.contributor.institutionTokyo Institute of Technology, Department of Materials Science and Engineering, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8552, Japan
kaust.personPiwonski, Hubert Marek
kaust.personHabuchi, Satoshi
kaust.grant.numberOSR-2016-2967-CRG5
dc.date.accepted2020-11-15
refterms.dateFOA2020-12-09T08:08:49Z
kaust.acknowledged.supportUnitKAUST Office of Sponsored Research (OSR)


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